8RJW

Human RAD52 open ring - ssDNA complex

  • Classification: DNA BINDING PROTEIN
  • Organism(s): Homo sapiens
  • Expression System: Escherichia coli
  • Mutation(s): No 

  • Deposited: 2023-12-21 Released: 2024-04-24 
  • Deposition Author(s): Liang, C.C., West, S.C.
  • Funding Organization(s): The Francis Crick Institute, Cancer Research UK, Medical Research Council (MRC, United Kingdom), Wellcome Trust, European Research Council (ERC), Biotechnology and Biological Sciences Research Council (BBSRC), Louis-Jeantet Foundation

Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.30 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.0 of the entry. See complete history. 


Literature

Mechanism of single-stranded DNA annealing by RAD52-RPA complex

Liang, C.C., Greenhough, L.A., Masino, L., Maslen, S., Bajrami, I., Tuppi, M., Skehel, M., Taylor, I.A., West, S.C.

(2024) Nature 


Macromolecules

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(by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
DNA repair protein RAD52 homolog
A, B, C, D, E
A, B, C, D, E, F, G, H, I
418Homo sapiensMutation(s): 0 
Gene Names: RAD52
UniProt & NIH Common Fund Data Resources
Find proteins for P43351 (Homo sapiens)
Explore P43351 
Go to UniProtKB:  P43351
PHAROS:  P43351
GTEx:  ENSG00000002016 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP43351
Sequence Annotations
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  • Reference Sequence

Find similar nucleic acids by:  Sequence   |   3D Structure  

Entity ID: 2
MoleculeChains LengthOrganismImage
ssDNA23Homo sapiens
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.30 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 
EM Software:
TaskSoftware PackageVersion
MODEL REFINEMENTPHENIX1.21_5207

Structure Validation

View Full Validation Report



View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
The Francis Crick InstituteUnited KingdomCC2098
Cancer Research UKUnited KingdomCC2098
Medical Research Council (MRC, United Kingdom)United KingdomCC2098
Wellcome TrustUnited KingdomCC2098
European Research Council (ERC)European UnionERC-ADG-666400
Biotechnology and Biological Sciences Research Council (BBSRC)United KingdomBB/W01355X/1
Louis-Jeantet FoundationSwitzerland--
Wellcome TrustUnited Kingdom206175/Z/17/Z

Revision History  (Full details and data files)

  • Version 1.0: 2024-04-24
    Type: Initial release