Farnesyl diphosphate phosphatase YisP

UniProtKB accession:  O06728

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UniProtKB description:  A farnesyl diphosphate (FPP) phosphatase. Involved in biofilm formation, its disruption blocks biofilm synthesis which is restored by exogenous farnesol (PubMed:25308276). Releases diphosphate from FPP, was initally suggested to be a squalene synthase. Diphosphate release is higher from FPP than geranyl pyrophosphate (GPP) or geranylgeranyl pyrophosphate (GGPP). Biofilm synthesis is partially restored by exogenous squalene, beta-carotene or retinol. Required for integrity of cell membrane lipid rafts (PubMed:20713508). Involved in spatial organization of membranes, required for the flotillin-like proteins FloT and FloA to function correctly (PubMed:23651456).