Annotations: 6UP7

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth R]	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8094448	4001858	SCOP2 (2022-06-29)
C [auth R]	SCOP2 Superfamily	G protein-coupled receptor-like	8094449	3000473	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00339	e6up7B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00339	ECOD (1.6)
B	PF02752	e6up7B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02752	ECOD (1.6)
C [auth R]	PF00001	e6up7R1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: PF00001	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF07421	Neurotensin/neuromedin N precursor (Pro-NT_NN)	Neurotensin/neuromedin N precursor	-	Family
B	PF00339	Arrestin (or S-antigen), N-terminal domain (Arrestin_N)	Arrestin (or S-antigen), N-terminal domain	Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.	Domain
B	PF02752	Arrestin (or S-antigen), C-terminal domain (Arrestin_C)	Arrestin (or S-antigen), C-terminal domain	Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.	Domain
C [auth R]	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	ARG-ARG-PRO-TYR-ILE-LEU	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity G protein-coupled receptor binding neuropeptide receptor binding neuropeptide activity hormone activity neuropeptide hormone activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway positive regulation of DNA-binding transcription factor activity cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway positive regulation of DNA-binding transcription factor activity cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of tube diameter multicellular organismal process system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance regulation of biological quality blood circulation regulation of anatomical structure size positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling	extracellular region cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle transport vesicle intracellular vesicle endomembrane system cytoplasmic vesicle cytoplasm vesicle axon extracellular region cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle transport vesicle intracellular vesicle endomembrane system cytoplasmic vesicle cytoplasm vesicle axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon cell junction neuron projection terminus
B	Beta-arrestin-1	protein binding binding arrestin family protein binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity GTPase regulator activity enzyme activator activity protein binding binding arrestin family protein binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity GTPase regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity angiotensin receptor binding signaling receptor binding G protein-coupled receptor binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding insulin-like growth factor receptor binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication cellular process ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling interleukin-6 production multicellular organismal process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of interleukin-6 production organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of interleukin-6 production negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process negative regulation of post-translational protein modification regulation of protein modification process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process primary metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization regulation of localization import into cell regulation of cellular component organization positive regulation of cellular component organization receptor internalization regulation of receptor internalization vesicle-mediated transport cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport endocytosis receptor-mediated endocytosis actomyosin structure organization actin cytoskeleton organization actin filament organization cellular component biogenesis organelle organization cellular component assembly actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly supramolecular fiber organization cytoskeleton organization small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process negative regulation of DNA-binding transcription factor activity RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process negative regulation of NF-kappaB transcription factor activity nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of molecular function nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of signaling negative regulation of cell communication cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway sensory perception of light stimulus system process sensory perception nervous system process visual perception negative regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of phosphorus metabolic process regulation of phosphorylation transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of macromolecule biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process negative adaptation of signaling pathway desensitization of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor internalization adaptation of signaling pathway G protein-coupled receptor signaling pathway	cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection clathrin-coated pit membrane endomembrane system intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle nucleus cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection clathrin-coated pit membrane endomembrane system intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle organelle membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane lysosome Golgi membrane Golgi apparatus nuclear body
C [auth R]	Neurotensin receptor type 1	peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled neurotensin receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity neuropeptide receptor activity protein-containing complex binding binding identical protein binding protein binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway regulation of localization positive regulation of arachidonic acid secretion transport cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway regulation of localization positive regulation of arachidonic acid secretion transport positive regulation of biological process regulation of lipid transport regulation of arachidonic acid secretion localization monocarboxylic acid transport positive regulation of secretion fatty acid transport icosanoid transport regulation of icosanoid secretion icosanoid secretion long-chain fatty acid transport positive regulation of icosanoid secretion organic anion transport carboxylic acid transport secretion arachidonate transport regulation of transport organic substance transport lipid localization lipid transport positive regulation of lipid localization establishment of localization regulation of fatty acid transport regulation of secretion positive regulation of organic acid transport organic acid transport positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization regulation of organic acid transport positive regulation of fatty acid transport arachidonic acid secretion adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior system process learning learning or memory nervous system process cognition regulation of calcium ion transport intracellular calcium ion homeostasis negative regulation of biological process negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion positive regulation of cellular process calcium ion transmembrane import into cytosol sequestering of calcium ion negative regulation of calcium ion transport cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport regulation of postsynaptic membrane potential regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic synaptic signaling positive regulation of inhibitory postsynaptic potential positive regulation of nervous system process regulation of multicellular organismal process regulation of biological quality modulation of inhibitory postsynaptic potential trans-synaptic signaling regulation of signaling cell surface receptor signaling pathway cell-cell signaling regulation of nervous system process chemical synaptic transmission regulation of response to stimulus anterograde trans-synaptic signaling inhibitory postsynaptic potential positive regulation of multicellular organismal process regulation of cell communication regulation of membrane potential negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of programmed cell death positive regulation of apoptotic process import into cell nitrogen compound transport carboxylic acid transmembrane transport aspartate transmembrane transport amino acid transmembrane transport C4-dicarboxylate transport D-aspartate transmembrane transport D-aspartate import across plasma membrane organic acid transmembrane transport import across plasma membrane D-amino acid transport amino acid transport dicarboxylic acid transport amino acid import across plasma membrane regulation of membrane depolarization membrane depolarization polyol metabolic process alcohol catabolic process catabolic process organic hydroxy compound metabolic process polyol catabolic process organophosphate catabolic process alcohol metabolic process inositol phosphate metabolic process organophosphate metabolic process organic hydroxy compound catabolic process phosphate-containing compound metabolic process inositol phosphate catabolic process small molecule metabolic process small molecule catabolic process phosphorus metabolic process organic substance catabolic process detection of external stimulus detection of stimulus involved in sensory perception of pain response to external stimulus sensory perception of temperature stimulus sensory perception of pain detection of temperature stimulus involved in sensory perception response to temperature stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of temperature stimulus response to abiotic stimulus detection of stimulus involved in sensory perception detection of temperature stimulus involved in sensory perception of pain L-amino acid transport L-glutamate import L-glutamate import across plasma membrane acidic amino acid transport L-alpha-amino acid transmembrane transport L-glutamate transmembrane transport multicellular organismal-level homeostasis temperature homeostasis regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure negative regulation of systemic arterial blood pressure blood circulation negative regulation of blood pressure positive regulation of amine transport gamma-aminobutyric acid transport regulation of amino acid transport gamma-aminobutyric acid secretion regulation of gamma-aminobutyric acid secretion positive regulation of gamma-aminobutyric acid secretion acid secretion amine transport positive regulation of amino acid transport regulation of amine transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of release of sequestered calcium ion into cytosol regulation of respiratory gaseous exchange respiratory gaseous exchange by respiratory system response to organic substance response to lipid response to chemical regulation of glutamate secretion positive regulation of secretion by cell secretion by cell regulation of secretion by cell glutamate secretion positive regulation of glutamate secretion export from cell regulation of inositol phosphate biosynthetic process positive regulation of phosphate metabolic process regulation of primary metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process polyol biosynthetic process positive regulation of phosphorus metabolic process regulation of alcohol biosynthetic process carbohydrate biosynthetic process primary metabolic process positive regulation of inositol phosphate biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process regulation of phosphorus metabolic process positive regulation of carbohydrate metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process small molecule biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process	symmetric synapse neuron to neuron synapse synapse cell junction cellular anatomical entity somatodendritic compartment cell body perikaryon neuronal cell body axon neuron projection axon terminus plasma membrane bounded cell projection presynapse symmetric synapse neuron to neuron synapse synapse cell junction cellular anatomical entity somatodendritic compartment cell body perikaryon neuronal cell body axon neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton neuron projection terminus cell surface cell periphery plasma membrane membrane membrane microdomain membrane raft membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system dendrite dendritic tree dendritic shaft neuron spine dendritic spine postsynapse cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane endoplasmic reticulum
D [auth V]	unidentified peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR008055	Neurotensin/neuromedin N	Family
B	IPR000698	Arrestin	Family
B	IPR011021	Arrestin-like, N-terminal	Domain
B	IPR014753	Arrestin, N-terminal	Homologous Superfamily
B	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B	IPR014752	Arrestin-like, C-terminal	Homologous Superfamily
B	IPR017864	Arrestin, conserved site	Conserved Site
B	IPR011022	Arrestin C-terminal-like domain	Domain
C [auth R]	IPR003985	Neurotensin type 1 receptor	Family
C [auth R]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
C [auth R]	IPR003984	Neurotensin receptor	Family
C [auth R]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C]	Pharos: P30990	Muscle Rigidity ovarian cancer schizophrenia chronic obstructive pulmonary disease head and neck cancer non-small cell lung carcinoma pituitary cancer attention deficit hyperactivity disorder, inattentive type lung cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor depressive disorder malignant ependymoma
B	Pharos: P49407	cirrhosis of liver pilocytic astrocytoma ulcerative colitis adrenal cortex carcinoma breast cancer Fibrosis, Liver large cell medulloblastoma lung carcinoma malignant glioma osteosarcoma astrocytic tumor glioblastoma lung adenocarcinoma major depressive disorder malignant mesothelioma cirrhosis of liver pilocytic astrocytoma ulcerative colitis adrenal cortex carcinoma breast cancer Fibrosis, Liver large cell medulloblastoma lung carcinoma malignant glioma osteosarcoma astrocytic tumor glioblastoma lung adenocarcinoma major depressive disorder malignant mesothelioma ovarian cancer tuberculosis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant ependymoma non-small cell lung carcinoma
C [auth R]	Pharos: P30989	Pain schizophrenia autism spectrum disorder

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], B, C [auth R]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B, C [auth R]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth C], B, C [auth R]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	NTSR1 neurotensin receptor in complex with β-arrestin1

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.