6MMV

Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyType 2 solute binding protein-like8036603 3000083 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyType 2 solute binding protein-like8036603 3000083 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF01094e6mmvA4 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
AF_UNCLASSIFIEDe6mmvA3 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
APF10613e6mmvA1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
CPF01094e6mmvC1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
CF_UNCLASSIFIEDe6mmvC3 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
CPF10613e6mmvC4 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
BF_UNCLASSIFIEDe6mmvB1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: F_UNCLASSIFIEDECOD (1.6)
BPF01094e6mmvB3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
BF_UNCLASSIFIEDe6mmvB4 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
BPF10613e6mmvB2 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
DF_UNCLASSIFIEDe6mmvD3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: F_UNCLASSIFIEDECOD (1.6)
DPF01094e6mmvD4 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
DF_UNCLASSIFIEDe6mmvD1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
DPF10613e6mmvD2 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
A, C
PF00497Bacterial extracellular solute-binding proteins, family 3 (SBP_bac_3)Bacterial extracellular solute-binding proteins, family 3This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. Th ...This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1].
Domain
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
PF00497Bacterial extracellular solute-binding proteins, family 3 (SBP_bac_3)Bacterial extracellular solute-binding proteins, family 3This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. Th ...This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1].
Domain
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
PF00497Bacterial extracellular solute-binding proteins, family 3 (SBP_bac_3)Bacterial extracellular solute-binding proteins, family 3This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. Th ...This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Glutamate receptor ionotropic, NMDA 1
Glutamate receptor ionotropic, NMDA 2A
Glutamate receptor ionotropic, NMDA 2A

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C
IPR001638Solute-binding protein family 3/N-terminal domain of MltFDomain
A, C
IPR028082Periplasmic binding protein-like IHomologous Superfamily
A, C
IPR001828Receptor, ligand binding regionDomain
A, C
IPR001320Ionotropic glutamate receptor, C-terminalDomain
A, C
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
A, C
IPR001508Ionotropic glutamate receptor, metazoaFamily
A, C
IPR015683Ionotropic glutamate receptorFamily
IPR018884Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomain
IPR001638Solute-binding protein family 3/N-terminal domain of MltFDomain
IPR028082Periplasmic binding protein-like IHomologous Superfamily
IPR001828Receptor, ligand binding regionDomain
IPR001320Ionotropic glutamate receptor, C-terminalDomain
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
IPR001508Ionotropic glutamate receptor, metazoaFamily
IPR015683Ionotropic glutamate receptorFamily
IPR018884Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomain
IPR001638Solute-binding protein family 3/N-terminal domain of MltFDomain
IPR028082Periplasmic binding protein-like IHomologous Superfamily
IPR001828Receptor, ligand binding regionDomain
IPR001320Ionotropic glutamate receptor, C-terminalDomain
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
IPR001508Ionotropic glutamate receptor, metazoaFamily
IPR015683Ionotropic glutamate receptorFamily