Annotations: 6ISB

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d6isbc_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set_9	e6isbA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_9	ECOD (1.6)
A	I-set_6	e6isbA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_6	ECOD (1.6)
B	V-set_9	e6isbB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_9	ECOD (1.6)
B	I-set_6	e6isbB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_6	ECOD (1.6)
C	V-set_9	e6isbC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_9	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	CD226 antigen	cell adhesion molecule binding protein binding binding protein-containing complex binding integrin binding signaling receptor binding kinase binding enzyme binding protein kinase binding identical protein binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing multicellular organismal process regulation of natural killer cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process cytokine production organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of cytokine production involved in immune response cellular metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process natural killer cell cytokine production cellular biosynthetic process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production regulation of multicellular organismal process cytokine production involved in immune response production of molecular mediator of immune response regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of natural killer cell cytokine production regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process cell recognition cellular response to stimulus signaling signal transduction cell communication positive regulation of cell communication immune response-regulating cell surface receptor signaling pathway positive regulation of signal transduction positive regulation of T cell receptor signaling pathway regulation of antigen receptor-mediated signaling pathway regulation of signal transduction immune response-activating signaling pathway immune response-regulating signaling pathway regulation of signaling cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway regulation of T cell receptor signaling pathway T cell receptor signaling pathway regulation of cell communication antigen receptor-mediated signaling pathway activation of immune response positive regulation of antigen receptor-mediated signaling pathway positive regulation of signaling adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response positive regulation of adaptive immune response positive regulation of immunoglobulin mediated immune response regulation of adaptive immune response regulation of B cell mediated immunity adaptive immune response immunoglobulin mediated immune response B cell mediated immunity positive regulation of mast cell activation regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation positive regulation of cell activation positive regulation of leukocyte activation mast cell activation regulation of mast cell activation cell adhesion positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response to tumor cell regulation of natural killer cell mediated cytotoxicity directed against tumor cell target regulation of natural killer cell mediated immune response to tumor cell positive regulation of immune response to tumor cell natural killer cell mediated immune response to tumor cell positive regulation of response to tumor cell positive regulation of natural killer cell mediated immune response to tumor cell regulation of response to tumor cell response to tumor cell regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target regulation of Fc receptor mediated stimulatory signaling pathway Fc receptor mediated stimulatory signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway regulation of type II interferon production type II interferon production positive regulation of type II interferon production	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C	IPR003599	Immunoglobulin subtype	Domain
A, B, C	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C	IPR013106	Immunoglobulin V-set domain	Domain
A, B, C	IPR042842	CD226 antigen	Family
A, B, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q15762	rheumatoid arthritis endometriosis colorectal cancer psoriasis Spontaneous abortion colorectal carcinoma hepatocellular carcinoma laryngeal squamous cell carcinoma lung carcinoma osteosarcoma systemic lupus erythematosus hypothyroidism primary biliary cholangitis sclerosing cholangitis tuberculosis rheumatoid arthritis endometriosis colorectal cancer psoriasis Spontaneous abortion colorectal carcinoma hepatocellular carcinoma laryngeal squamous cell carcinoma lung carcinoma osteosarcoma systemic lupus erythematosus hypothyroidism primary biliary cholangitis sclerosing cholangitis tuberculosis cutaneous lupus erythematosus Hashimoto thyroiditis inflammatory bowel disease lung cancer MALT lymphoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.