Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
D [auth C]SCOP2B SuperfamilyCore histone-like8036586 3001387 SCOP2B (2022-06-29)
E [auth D]SCOP2B SuperfamilyCore histone-like8036586 3001387 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyCore histone-like8103853 3001387 SCOP2B (2022-06-29)
I [auth H]SCOP2B SuperfamilyCore histone-like8103853 3001387 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyCore histone-like8036585 3001387 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyCore histone-like8036585 3001387 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyCore histone-like8036588 3001387 SCOP2B (2022-06-29)
G [auth F]SCOP2B SuperfamilyCore histone-like8036588 3001387 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
D [auth C]PF15511e6genC1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF15511ECOD (1.6)
E [auth D]PF15511e6genD1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF15511ECOD (1.6)
H [auth G]PF00125e6genG1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF00125ECOD (1.6)
I [auth H]PF00125e6genH1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF00125ECOD (1.6)
M [auth R]PF00022e6genR2 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00022ECOD (1.6)
P [auth U]PF06068e6genU2 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF06068ECOD (1.6)
P [auth U]PF17856e6genU3 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: PF17856ECOD (1.6)
P [auth U]PF06068e6genU1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF06068ECOD (1.6)
R [auth W]PF06068e6genW3 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF06068ECOD (1.6)
R [auth W]PF17856e6genW1 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: PF17856ECOD (1.6)
R [auth W]PF06068e6genW2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF06068ECOD (1.6)
T [auth Y]PF06068e6genY3 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF06068ECOD (1.6)
T [auth Y]PF17856e6genY1 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: PF17856ECOD (1.6)
T [auth Y]PF06068e6genY2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF06068ECOD (1.6)
O [auth T]PF06068e6genT2 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF06068ECOD (1.6)
O [auth T]PF17856e6genT3 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: PF17856ECOD (1.6)
O [auth T]PF06068e6genT1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF06068ECOD (1.6)
Q [auth V]PF06068e6genV1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF06068ECOD (1.6)
Q [auth V]PF17856e6genV3 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: PF17856ECOD (1.6)
Q [auth V]PF06068e6genV2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF06068ECOD (1.6)
S [auth X]PF06068e6genX2 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: PF06068ECOD (1.6)
S [auth X]PF17856e6genX3 A: alpha arraysX: Histone-likeH: Histone-relatedT: AAA+ ATPase lid domainF: PF17856ECOD (1.6)
S [auth X]PF06068e6genX1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF06068ECOD (1.6)
B [auth A]PF00125e6genA1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF00125ECOD (1.6)
C [auth B]PF00125e6genB1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF00125ECOD (1.6)
F [auth E]PF00125,PF16211e6genE1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF00125,PF16211ECOD (1.6)
G [auth F]PF00125,PF16211e6genF1 A: alpha arraysX: Histone-likeH: Histone-relatedT: HistoneF: PF00125,PF16211ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
D [auth C],
E [auth D]
PF15511Centromere kinetochore component CENP-T histone fold (CENP-T_C)Centromere kinetochore component CENP-T histone foldCENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly asso ...CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes. This domain is the C-terminal histone fold domain of CENP-T, which associates with chromatin [2-3].
Domain
H [auth G],
I [auth H]
PF00125Core histone H2A/H2B/H3/H4 (Histone)Core histone H2A/H2B/H3/H4- Domain
M [auth R]PF00022Actin (Actin)Actin- Family
P [auth U],
R [auth W],
T [auth Y]
PF06068TIP49 P-loop domain (TIP49)TIP49 P-loop domainThis family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].
Domain
P [auth U],
R [auth W],
T [auth Y]
PF17856TIP49 AAA-lid domain (TIP49_C)TIP49 AAA-lid domainThis family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].
Domain
O [auth T],
Q [auth V],
S [auth X]
PF06068TIP49 P-loop domain (TIP49)TIP49 P-loop domainThis family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].
Domain
O [auth T],
Q [auth V],
S [auth X]
PF17856TIP49 AAA-lid domain (TIP49_C)TIP49 AAA-lid domainThis family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].
Domain
B [auth A],
C [auth B]
PF00125Core histone H2A/H2B/H3/H4 (Histone)Core histone H2A/H2B/H3/H4- Domain
F [auth E],
G [auth F]
PF16211C-terminus of histone H2A (Histone_H2A_C)C-terminus of histone H2A- Family
F [auth E],
G [auth F]
PF00125Core histone H2A/H2B/H3/H4 (Histone)Core histone H2A/H2B/H3/H4- Domain
L [auth M]PF00271Helicase conserved C-terminal domain (Helicase_C)Helicase conserved C-terminal domainThe Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.Domain
L [auth M]PF00176SNF2-related domain (SNF2-rel_dom)SNF2-related domainThis domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as w ...This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1)[1,2,3]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
D [auth C],
E [auth D]
Histone H4
H [auth G],
I [auth H]
Histone H2B.1
K [auth J]DNA (173-MER)---
M [auth R]Actin-like protein ARP6
P [auth U],
R [auth W],
T [auth Y]
RuvB-like protein 2
A [auth Z]Vacuolar protein sorting-associated protein 72---
N [auth S]Vacuolar protein sorting-associated protein 71
O [auth T],
Q [auth V],
S [auth X]
RuvB-like protein 1
B [auth A],
C [auth B]
Histone H3
F [auth E],
G [auth F]
Histone H2A.1
J [auth I]DNA (173-MER)---
L [auth M]Helicase SWR1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
D [auth C],
E [auth D]
IPR009072Histone-foldHomologous Superfamily
D [auth C],
E [auth D]
IPR035425CENP-T/Histone H4, histone foldDomain
D [auth C],
E [auth D]
IPR001951Histone H4Family
D [auth C],
E [auth D]
IPR019809Histone H4, conserved siteConserved Site
H [auth G],
I [auth H]
IPR009072Histone-foldHomologous Superfamily
H [auth G],
I [auth H]
IPR007125Histone H2A/H2B/H3Domain
H [auth G],
I [auth H]
IPR000558Histone H2BFamily
M [auth R]IPR043129ATPase, nucleotide binding domainHomologous Superfamily
M [auth R]IPR004000Actin familyFamily
P [auth U],
R [auth W],
T [auth Y]
IPR041048RuvB-like, AAA-lid domainDomain
P [auth U],
R [auth W],
T [auth Y]
IPR042487RuvBL1/2, DNA/RNA binding domainHomologous Superfamily
P [auth U],
R [auth W],
T [auth Y]
IPR027238RuvB-likeFamily
P [auth U],
R [auth W],
T [auth Y]
IPR010339TIP49, P-loop domainDomain
P [auth U],
R [auth W],
T [auth Y]
IPR003593AAA+ ATPase domainDomain
P [auth U],
R [auth W],
T [auth Y]
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
N [auth S]IPR039723Vps71/ZNHIT1Family
N [auth S]IPR007529Zinc finger, HIT-typeDomain
O [auth T],
Q [auth V],
S [auth X]
IPR041048RuvB-like, AAA-lid domainDomain
O [auth T],
Q [auth V],
S [auth X]
IPR042487RuvBL1/2, DNA/RNA binding domainHomologous Superfamily
O [auth T],
Q [auth V],
S [auth X]
IPR027238RuvB-likeFamily
O [auth T],
Q [auth V],
S [auth X]
IPR010339TIP49, P-loop domainDomain
O [auth T],
Q [auth V],
S [auth X]
IPR003593AAA+ ATPase domainDomain
O [auth T],
Q [auth V],
S [auth X]
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
B [auth A],
C [auth B]
IPR009072Histone-foldHomologous Superfamily
B [auth A],
C [auth B]
IPR007125Histone H2A/H2B/H3Domain
B [auth A],
C [auth B]
IPR000164Histone H3/CENP-AFamily
F [auth E],
G [auth F]
IPR009072Histone-foldHomologous Superfamily
F [auth E],
G [auth F]
IPR007125Histone H2A/H2B/H3Domain
F [auth E],
G [auth F]
IPR002119Histone H2AFamily
F [auth E],
G [auth F]
IPR032454Histone H2A, C-terminal domainDomain
F [auth E],
G [auth F]
IPR032458Histone H2A conserved siteConserved Site
L [auth M]IPR000330SNF2, N-terminalDomain
L [auth M]IPR001650Helicase, C-terminal domain-likeDomain
L [auth M]IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
L [auth M]IPR049730SNF2/RAD5-like, C-terminal helicase domainDomain
L [auth M]IPR014012Helicase/SANT-associated domainDomain
L [auth M]IPR038718SNF2-like, N-terminal domain superfamilyHomologous Superfamily
L [auth M]IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily