Annotations: 6CV7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6cv7A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00028	e6cv7A3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
A	PF18432	e6cv7A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18432	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain
A	PF18432	Extracellular Cadherin domain (ECD)	Extracellular Cadherin domain	This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs [1]. These repeats are structurally similar, but not id ...	This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs [1]. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protocadherin-15	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development animal organ morphogenesis system development developmental process embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation ear development embryonic morphogenesis nervous system development tissue development inner ear receptor cell differentiation generation of neurons auditory receptor cell development cellular developmental process cell development embryo development cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization animal organ development inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis cellular process inner ear receptor cell stereocilium organization behavior locomotory behavior response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance tissue morphogenesis morphogenesis of an epithelium reflex response to external stimulus righting reflex sensory perception of light stimulus system process sensory perception nervous system process organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly non-motile cilium assembly cilium organization cell projection assembly startle response neuromuscular process detection of external stimulus detection of mechanical stimulus involved in sensory perception of sound response to mechanical stimulus detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception sensory perception of sound multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance equilibrioception neuromuscular process controlling balance cell adhesion visual perception detection of mechanical stimulus involved in equilibrioception cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules adult walking behavior adult locomotory behavior adult behavior walking behavior multicellular organism growth developmental growth growth actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization	membrane cellular anatomical entity cell periphery plasma membrane intracellular anatomical structure cytoplasm membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor outer segment plasma membrane bounded cell projection cell projection membrane cellular anatomical entity cell periphery plasma membrane intracellular anatomical structure cytoplasm membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle synapse cell junction stereocilium actin-based cell projection stereocilium bundle cluster of actin-based cell projections extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A	IPR020894	Cadherin conserved site	Conserved Site
A	IPR030718	Extracellular cadherin domain superfamily	Homologous Superfamily
A	IPR041149	Extracellular cadherin domain	Domain
A	IPR002126	Cadherin-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.