5WYO

Solution structure of E.coli HdeA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5wyoa_	All alpha proteins	Protein HNS-dependent expression A	HdeA	Protein HNS-dependent expression A	HdeA	(Escherichia coli O157:H7 ) [TaxId: 83334 ],	SCOPe (2.08)
B	d5wyob_	All alpha proteins	Protein HNS-dependent expression A	HdeA	Protein HNS-dependent expression A	HdeA	(Escherichia coli O157:H7 ) [TaxId: 83334 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	HdeA-like	8091086	4001014	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HdeA-like	8091087	3000453	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	HdeA-like	8037689	3000453	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HdeA-like	8037689	3000453	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06411	e5wyoA1	A: alpha superhelices	X: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin-like	H: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin/Protein HNS-dependent expression A HdeA	T: Protein HNS-dependent expression A HdeA	F: PF06411	ECOD (1.6)
B	PF06411	e5wyoB1	A: alpha superhelices	X: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin-like	H: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin/Protein HNS-dependent expression A HdeA	T: Protein HNS-dependent expression A HdeA	F: PF06411	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.890.10	Mainly Alpha	Orthogonal Bundle	10k-s Protein, Hypothetical Protein A	Chain A	CATH (4.3.0)
B	1.10.890.10	Mainly Alpha	Orthogonal Bundle	10k-s Protein, Hypothetical Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06411	HdeA/HdeB family (HdeA)	HdeA/HdeB family	HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localised in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that H ...	HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localised in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS [1,2]. This family also contains HdeB [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Acid stress chaperone HdeA	unfolded protein binding protein binding binding identical protein binding protein homodimerization activity protein dimerization activity protein folding chaperone	cellular response to stimulus response to stimulus cellular response to chemical stress response to acidic pH cellular stress response to acidic pH cellular response to environmental stimulus cellular response to chemical stimulus cellular response to stress response to pH response to stress response to chemical cellular response to pH cellular process response to abiotic stimulus cellular response to stimulus response to stimulus cellular response to chemical stress response to acidic pH cellular stress response to acidic pH cellular response to environmental stimulus cellular response to chemical stimulus cellular response to stress response to pH response to stress response to chemical cellular response to pH cellular process response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process	outer membrane-bounded periplasmic space cell envelope periplasmic space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038303	HNS-dependent expression A/B superfamily	Homologous Superfamily
A, B	IPR036831	HNS-dependent expression A superfamily	Homologous Superfamily
A, B	IPR024972	HNS-dependent expression A	Family
A, B	IPR010486	HNS-dependent expression A/B	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.