Annotations: 5LKI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18276	e5lkiA4	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF18276	ECOD (1.6)
A	PF18518	e5lkiA5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18518	ECOD (1.6)
A	PF18413	e5lkiA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF18413	ECOD (1.6)
A	PF18276	e5lkiA1	A: alpha bundles	X: TcA alpha pore-forming domain (From Topology)	H: TcA alpha pore-forming domain (From Topology)	T: TcA alpha pore-forming domain	F: PF18276	ECOD (1.6)
A	F_UNCLASSIFIED	e5lkiA6	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF03538,PF20220	e5lkiA3	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: PF03538,PF20220	ECOD (1.6)
B	PF18276	e5lkiB3	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF18276	ECOD (1.6)
B	PF18518	e5lkiB4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18518	ECOD (1.6)
B	PF18413	e5lkiB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF18413	ECOD (1.6)
B	PF18276	e5lkiB1	A: alpha bundles	X: TcA alpha pore-forming domain (From Topology)	H: TcA alpha pore-forming domain (From Topology)	T: TcA alpha pore-forming domain	F: PF18276	ECOD (1.6)
B	F_UNCLASSIFIED	e5lkiB6	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF03538,PF20220	e5lkiB5	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: PF03538,PF20220	ECOD (1.6)
C	PF18276	e5lkiC3	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF18276	ECOD (1.6)
C	PF18518	e5lkiC4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18518	ECOD (1.6)
C	PF18413	e5lkiC2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF18413	ECOD (1.6)
C	PF18276	e5lkiC1	A: alpha bundles	X: TcA alpha pore-forming domain (From Topology)	H: TcA alpha pore-forming domain (From Topology)	T: TcA alpha pore-forming domain	F: PF18276	ECOD (1.6)
C	F_UNCLASSIFIED	e5lkiC6	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF03538,PF20220	e5lkiC5	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: PF03538,PF20220	ECOD (1.6)
E	PF18276	e5lkiE4	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF18276	ECOD (1.6)
E	PF18518	e5lkiE5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18518	ECOD (1.6)
E	PF18413	e5lkiE2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF18413	ECOD (1.6)
E	PF18276	e5lkiE1	A: alpha bundles	X: TcA alpha pore-forming domain (From Topology)	H: TcA alpha pore-forming domain (From Topology)	T: TcA alpha pore-forming domain	F: PF18276	ECOD (1.6)
E	F_UNCLASSIFIED	e5lkiE7	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF03538,PF20220	e5lkiE3	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: PF03538,PF20220	ECOD (1.6)
D	PF18276	e5lkiD4	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF18276	ECOD (1.6)
D	PF18518	e5lkiD5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18518	ECOD (1.6)
D	PF18413	e5lkiD2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF18413	ECOD (1.6)
D	PF18276	e5lkiD1	A: alpha bundles	X: TcA alpha pore-forming domain (From Topology)	H: TcA alpha pore-forming domain (From Topology)	T: TcA alpha pore-forming domain	F: PF18276	ECOD (1.6)
D	F_UNCLASSIFIED	e5lkiD6	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF03538,PF20220	e5lkiD3	A: alpha complex topology	X: TcA alpha-helical shell domain (From Topology)	H: TcA alpha-helical shell domain (From Topology)	T: TcA alpha-helical shell domain	F: PF03538,PF20220	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF20220	ABC toxin N-terminal region (ABC_toxin_N)	ABC toxin N-terminal region	-	Family
A, B, C, D, E	PF18276	Tc toxin complex TcA C-terminal TcB-binding domain (TcA_TcB_BD)	Tc toxin complex TcA C-terminal TcB-binding domain	This domain is found in the C-terminal region of the Tc toxin TcA, present in Photorhabdus luminescens. Tc Toxin complexes bind to the cell surface, are endocytosed and perforate the host endosomal membrane by forming channels that translocate toxic ...	This domain is found in the C-terminal region of the Tc toxin TcA, present in Photorhabdus luminescens. Tc Toxin complexes bind to the cell surface, are endocytosed and perforate the host endosomal membrane by forming channels that translocate toxic enzymes into the host. This domain is responsible for binding to toxin TcB. Binding of TcA to TcB/TcC opens the beta-propeller gate [1].	Domain
A, B, C, D, E	PF18413	Neuraminidase-like domain (Neuraminidase)	Neuraminidase-like domain	-	Repeat
A, B, C, D, E	PF18518	TcA receptor binding domain (TcA_RBD)	TcA receptor binding domain	Tc toxin complexes are virulence factors of many bacteria such as the plague pathogen Yersinia pestis. Tc toxins are composed of TcA, TcB and TcC subunits. TcA forms a large bell-shaped pentameric structure and enters the membrane like a syringe, for ...	Tc toxin complexes are virulence factors of many bacteria such as the plague pathogen Yersinia pestis. Tc toxins are composed of TcA, TcB and TcC subunits. TcA forms a large bell-shaped pentameric structure and enters the membrane like a syringe, forming a translocation channel through which the cytotoxic domain is probably transported into the cytoplasm. TcA has four receptor-binding domains. This domain is one of 4 receptor binding domains found in TcA. All four domains have an immunoglobulin (Ig)-like beta-sandwich fold of two sheets with antiparallel beta-strands. The domains are structurally reminiscent of the receptor-binding domains of the diphtheria and anthrax toxins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	TcdA1	identical protein binding protein binding binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR018003	Insecticidal toxin complex/plasmid virulence protein	Family
A, B, C, D, E	IPR041079	Neuraminidase-like domain	Domain
A, B, C, D, E	IPR040840	Tc toxin complex TcA, C-terminal TcB-binding domain	Domain
A, B, C, D, E	IPR046839	ABC toxin, N-terminal domain	Domain
A, B, C, D, E	IPR041568	TcA receptor binding domain	Domain