Annotations: 5I50

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8043846	3001962	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8043846	3001962	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HLH_1	e5i50A1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH_1	ECOD (1.6)
B	HLH_1	e5i50B1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.280.10	Few Secondary Structures	Irregular	MYOD Basic-Helix-Loop-Helix Domain, subunit B	Helix-loop-helix DNA-binding domain	CATH (4.3.0)
B	4.10.280.10	Few Secondary Structures	Irregular	MYOD Basic-Helix-Loop-Helix Domain, subunit B	Helix-loop-helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00010	Helix-loop-helix DNA-binding domain (HLH)	Helix-loop-helix DNA-binding domain	-	Domain
A, B	PF02344	Myc leucine zipper domain (Myc-LZ)	Myc leucine zipper domain	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Myc proto-oncogene protein	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding core promoter sequence-specific DNA binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding core promoter sequence-specific DNA binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein-containing complex binding protein dimerization activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity molecular function activator activity molecular function regulator activity transcription regulator activator activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding SCF ubiquitin ligase complex binding DNA-binding transcription factor binding E-box binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis negative regulation of transcription initiation by RNA polymerase II regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of DNA-templated transcription initiation transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of transcription initiation by RNA polymerase II negative regulation of DNA-templated transcription initiation response to chemical response to xenobiotic stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of stress-activated MAPK cascade regulation of cellular response to stress regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication stress-activated MAPK cascade regulation of intracellular signal transduction regulation of response to stress intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade negative regulation of signal transduction regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus negative regulation of stress-activated protein kinase signaling cascade MAPK cascade regulation of cell communication negative regulation of MAPK cascade protein-DNA complex organization cellular component organization cellular component disassembly protein-containing complex organization protein-DNA complex disassembly protein-containing complex disassembly cellular component organization or biogenesis positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of cellular biosynthetic process response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus regulation of miRNA metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription positive regulation of RNA biosynthetic process ncRNA metabolic process regulation of miRNA transcription fibroblast apoptotic process apoptotic process cell death programmed cell death regulation of catalytic activity regulation of transferase activity regulation of DNA biosynthetic process DNA metabolic process regulation of molecular function positive regulation of DNA metabolic process DNA biosynthetic process regulation of DNA metabolic process regulation of telomerase activity positive regulation of molecular function positive regulation of telomerase activity positive regulation of transferase activity positive regulation of catalytic activity positive regulation of DNA biosynthetic process mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process negative regulation of cell population proliferation fibroblast proliferation cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of fibroblast proliferation cellular response to xenobiotic stimulus myeloid leukocyte differentiation regulation of leukocyte differentiation multicellular organismal process cellular developmental process regulation of developmental process cell development mononuclear cell differentiation regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation anatomical structure development regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation monocyte differentiation negative regulation of hemopoiesis negative regulation of monocyte differentiation developmental process regulation of multicellular organismal development regulation of monocyte differentiation negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development animal organ morphogenesis epithelial tube morphogenesis nephron development system development nephron epithelium development ureteric bud development epithelium development tube development mesonephros development animal organ development morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium negative regulation of cell division cell division regulation of cell division positive regulation of transcription by RNA polymerase II regulation of somatic stem cell population maintenance regulation of stem cell population maintenance stem cell population maintenance somatic stem cell population maintenance maintenance of cell number negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process ERK1 and ERK2 cascade regulation of cell cycle process regulation of cell cycle organelle organization chromosome organization positive regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of cell communication positive regulation of signal transduction positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator intrinsic apoptotic signaling pathway positive regulation of programmed cell death positive regulation of intracellular signal transduction signal transduction by p53 class mediator positive regulation of apoptotic process apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway positive regulation of signaling positive regulation of mesenchymal cell proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of telomere maintenance regulation of cellular component organization telomere organization regulation of chromosome organization regulation of organelle organization telomere maintenance positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis chromatin organization DNA methylation-dependent heterochromatin formation chromatin remodeling heterochromatin formation epigenetic regulation of gene expression negative regulation of gene expression facultative heterochromatin formation negative regulation of gene expression, epigenetic regulation of kidney development metanephric cap morphogenesis mesenchyme development regulation of metanephric cap mesenchymal cell proliferation kidney mesenchyme development positive regulation of developmental process metanephros development metanephric mesenchyme morphogenesis positive regulation of cell proliferation involved in kidney development mesenchyme morphogenesis metanephric mesenchyme development positive regulation of kidney development cell proliferation involved in kidney development regulation of cell proliferation involved in kidney development cell proliferation involved in metanephros development metanephric cap development positive regulation of metanephric cap mesenchymal cell proliferation positive regulation of multicellular organismal process metanephric cap mesenchymal cell proliferation involved in metanephros development kidney mesenchyme morphogenesis response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV response to endogenous stimulus response to growth factor response to ionizing radiation response to gamma radiation	intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle RNA polymerase II transcription repressor complex nucleus nuclear protein-containing complex intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle RNA polymerase II transcription repressor complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle transcription repressor complex membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen nucleoplasm RNA polymerase II transcription regulator complex Myc-Max complex
C	DNA (5'-D(PCPAPCPCPCPGPGPTPCPAPCPGPTPGPGPCPCPTPAPCPAPC)-3')	-	-	-
D	DNA (5'-D(PGPTPGPTPAPGPGPCPCPAPCPGPTPGPAPCPCPGPGPGPTPG)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR002418	Transcription regulator Myc	Family
A, B	IPR003327	Leucine zipper, Myc	Domain
A, B	IPR012682	Transcription regulator Myc, N-terminal	Domain
A, B	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P01106	cancer Burkitt lymphoma acute myeloid leukemia medulloblastoma myelodysplastic syndrome osteosarcoma glioblastoma cleft palate neuroblastoma hypertrophic cardiomyopathy angiosarcoma ovarian cancer plasma cell myeloma granular cell carcinoma Chromosome Breakage cancer Burkitt lymphoma acute myeloid leukemia medulloblastoma myelodysplastic syndrome osteosarcoma glioblastoma cleft palate neuroblastoma hypertrophic cardiomyopathy angiosarcoma ovarian cancer plasma cell myeloma granular cell carcinoma Chromosome Breakage adult medulloblastoma cutaneous neuroendocrine carcinoma endometrial carcinoma malignant colon neoplasm giant cell glioblastoma carcinoma cervical cancer prostate cancer medullomyoblastoma with myogenic differentiation adenocarcinoma squamous cell carcinoma trabecular adenocarcinoma urinary bladder cancer autosomal dominant polycystic kidney disease gastric cancer primitive neuroectodermal tumor childhood medulloblastoma melanotic medulloblastoma sarcomatoid carcinoma tubular adenocarcinoma liver cancer non-small cell lung carcinoma B-cell chronic lymphocytic leukemia lung disease bone disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia exocrine pancreatic carcinoma breast cancer gastric neoplasm malignant glioma prostate adenocarcinoma hepatocellular carcinoma hereditary diffuse gastric adenocarcinoma acute T cell leukemia sinusitis stomach disease intestinal disease colonic neoplasm undifferentiated carcinoma large cell medulloblastoma congestive heart failure urinary bladder neoplasm oligodendroglioma liver neoplasm atypical teratoid rhabdoid tumor ovarian carcinoma lung benign neoplasm benign colon neoplasm pancreatic intraductal papillary-mucinous carcinoma bone osteosarcoma pancreatic neoplasm breast disease polycystic kidney disease 2 fatty liver disease hematologic disease psoriasis myopathy invasive ductal breast carcinoma colorectal cancer cribriform carcinoma desmoplastic/nodular medulloblastoma ovarian disease lung carcinoma benign neoplasm pancreatic intraductal papillary-mucinous neoplasm lymphatic system disease brain disease pilocytic astrocytoma eye disease malignant ependymoma malignant pancreatic neoplasm prostate disease cleft lip nasopharyngeal carcinoma kidney disease adrenal cortex carcinoma common variable immunodeficiency urinary bladder disease allergic rhinitis cribriform carcinoma of breast uterine disease liver disease astrocytic tumor lung adenocarcinoma ovarian neoplasm endometrial cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.