Annotations: 5HSA

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05199	e5hsaA1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
A	PF00732	e5hsaA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
B	PF05199	e5hsaB2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
B	PF00732	e5hsaB3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
C	PF05199	e5hsaC2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
C	PF00732	e5hsaC3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
D	PF05199	e5hsaD2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
D	PF00732	e5hsaD3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
E	PF05199	e5hsaE2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
E	PF00732	e5hsaE3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
F	PF05199	e5hsaF2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
F	PF00732	e5hsaF3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
G	PF05199	e5hsaG2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
G	PF00732	e5hsaG3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)
H	PF05199	e5hsaH2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
H	PF00732	e5hsaH3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00732	GMC oxidoreductase (GMC_oxred_N)	GMC oxidoreductase	This family of proteins bind FAD as a cofactor.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF05199	GMC oxidoreductase (GMC_oxred_C)	GMC oxidoreductase	This domain found associated with Pfam:PF00732.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Alcohol oxidase 1	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors alcohol oxidase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	methane catabolic process catabolic process hydrocarbon catabolic process cellular metabolic process methane metabolic process alkane catabolic process hydrocarbon metabolic process cellular catabolic process organic substance metabolic process cellular alkane metabolic process metabolic process cellular process organic substance catabolic process organic hydroxy compound metabolic process methane catabolic process catabolic process hydrocarbon catabolic process cellular metabolic process methane metabolic process alkane catabolic process hydrocarbon metabolic process cellular catabolic process organic substance metabolic process cellular alkane metabolic process metabolic process cellular process organic substance catabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process methanol metabolic process primary alcohol metabolic process	peroxisomal matrix membrane-bounded organelle intracellular anatomical structure peroxisome membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle microbody lumen microbody cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000172	Glucose-methanol-choline oxidoreductase, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012132	Glucose-methanol-choline oxidoreductase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.