5GRS

Complex structure of the fission yeast SREBP-SCAP binding domains

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth B]	F_UNCLASSIFIED	e5grsB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth C]	F_UNCLASSIFIED	e5grsC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth D]	F_UNCLASSIFIED	e5grsD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth E]	PF09427	e5grsE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain (From Topology)	T: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain	F: PF09427	ECOD (1.6)
J [auth F]	PF09427	e5grsF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain (From Topology)	T: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain	F: PF09427	ECOD (1.6)
K [auth G]	PF09427	e5grsG1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain (From Topology)	T: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain	F: PF09427	ECOD (1.6)
L [auth H]	PF09427	e5grsH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain (From Topology)	T: Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain	F: PF09427	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
I [auth E], J [auth F], K [auth G], L [auth H]	PF09427	Domain of unknown function (DUF2014) (DUF2014)	Domain of unknown function (DUF2014)	This domain is found at the C terminal of a family of ER membrane bound transcription factors called sterol regulatory element binding proteins (SREBP).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D]	Sterol regulatory element-binding protein cleavage-activating protein	sterol binding binding organic cyclic compound binding steroid binding lipid binding	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process regulation of cellular process regulation of lipid metabolic process sterol metabolic process regulation of primary metabolic process positive regulation of metabolic process cellular lipid biosynthetic process regulation of small molecule metabolic process organic substance biosynthetic process organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process regulation of cellular process regulation of lipid metabolic process sterol metabolic process regulation of primary metabolic process positive regulation of metabolic process cellular lipid biosynthetic process regulation of small molecule metabolic process organic substance biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process regulation of biological process regulation of alcohol biosynthetic process cellular metabolic process regulation of cellular metabolic process phytosteroid biosynthetic process positive regulation of steroid biosynthetic process biosynthetic process sterol biosynthetic process regulation of sterol biosynthetic process organic cyclic compound biosynthetic process cellular lipid metabolic process regulation of metabolic process regulation of steroid biosynthetic process organic hydroxy compound metabolic process positive regulation of biological process lipid biosynthetic process alcohol metabolic process positive regulation of cellular metabolic process ergosterol biosynthetic process positive regulation of biosynthetic process ergosterol metabolic process steroid biosynthetic process positive regulation of cellular process regulation of biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process positive regulation of ergosterol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process regulation of ergosterol biosynthetic process biological regulation secondary alcohol metabolic process positive regulation of lipid biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process positive regulation of steroid metabolic process cellular process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process cellular response to stimulus response to stimulus cellular response to sterol depletion signaling response to sterol depletion cell communication SREBP signaling pathway cellular response to stress response to stress ER-nucleus signaling pathway signal transduction response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus regulation of cholesterol biosynthetic process regulation of cholesterol metabolic process cholesterol metabolic process cholesterol biosynthetic process	membrane-bounded organelle intracellular anatomical structure organelle subcompartment cytoplasmic side of membrane membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane-bounded organelle intracellular anatomical structure organelle subcompartment cytoplasmic side of membrane membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane protein-containing complex membrane protein complex SREBP-SCAP complex Golgi membrane Golgi apparatus bounding membrane of organelle
B [auth I], D [auth J], F [auth K], H [auth L]	Sterol regulatory element-binding protein cleavage-activating protein	sterol binding binding organic cyclic compound binding steroid binding lipid binding	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process regulation of cellular process regulation of lipid metabolic process sterol metabolic process regulation of primary metabolic process positive regulation of metabolic process cellular lipid biosynthetic process regulation of small molecule metabolic process organic substance biosynthetic process organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process regulation of cellular process regulation of lipid metabolic process sterol metabolic process regulation of primary metabolic process positive regulation of metabolic process cellular lipid biosynthetic process regulation of small molecule metabolic process organic substance biosynthetic process positive regulation of lipid metabolic process small molecule metabolic process regulation of biological process regulation of alcohol biosynthetic process cellular metabolic process regulation of cellular metabolic process phytosteroid biosynthetic process positive regulation of steroid biosynthetic process biosynthetic process sterol biosynthetic process regulation of sterol biosynthetic process organic cyclic compound biosynthetic process cellular lipid metabolic process regulation of metabolic process regulation of steroid biosynthetic process organic hydroxy compound metabolic process positive regulation of biological process lipid biosynthetic process alcohol metabolic process positive regulation of cellular metabolic process ergosterol biosynthetic process positive regulation of biosynthetic process ergosterol metabolic process steroid biosynthetic process positive regulation of cellular process regulation of biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process positive regulation of ergosterol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process regulation of ergosterol biosynthetic process biological regulation secondary alcohol metabolic process positive regulation of lipid biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process positive regulation of steroid metabolic process cellular process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process cellular response to stimulus response to stimulus cellular response to sterol depletion signaling response to sterol depletion cell communication SREBP signaling pathway cellular response to stress response to stress ER-nucleus signaling pathway signal transduction response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus regulation of cholesterol biosynthetic process regulation of cholesterol metabolic process cholesterol metabolic process cholesterol biosynthetic process	membrane-bounded organelle intracellular anatomical structure organelle subcompartment cytoplasmic side of membrane membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane-bounded organelle intracellular anatomical structure organelle subcompartment cytoplasmic side of membrane membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane protein-containing complex membrane protein complex SREBP-SCAP complex Golgi membrane Golgi apparatus bounding membrane of organelle
I [auth E], J [auth F], K [auth G], L [auth H]	Sterol regulatory element-binding protein 1	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein dimerization activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	regulation of steroid biosynthetic process regulation of cellular process organic hydroxy compound metabolic process regulation of lipid metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process alcohol metabolic process ergosterol biosynthetic process regulation of primary metabolic process cellular lipid biosynthetic process organic substance metabolic process regulation of small molecule metabolic process organic substance biosynthetic process regulation of steroid biosynthetic process regulation of cellular process organic hydroxy compound metabolic process regulation of lipid metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process alcohol metabolic process ergosterol biosynthetic process regulation of primary metabolic process cellular lipid biosynthetic process organic substance metabolic process regulation of small molecule metabolic process organic substance biosynthetic process small molecule metabolic process ergosterol metabolic process steroid biosynthetic process regulation of biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process regulation of biological process regulation of alcohol biosynthetic process small molecule biosynthetic process regulation of ergosterol biosynthetic process regulation of steroid metabolic process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process organic cyclic compound metabolic process phytosteroid biosynthetic process secondary alcohol metabolic process biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process regulation of sterol biosynthetic process organic cyclic compound biosynthetic process alcohol biosynthetic process cellular lipid metabolic process metabolic process cellular process regulation of lipid biosynthetic process regulation of metabolic process lipid metabolic process cellular response to stimulus response to stimulus cellular response to sterol depletion signaling response to sterol depletion cell communication SREBP signaling pathway cellular response to stress response to stress ER-nucleus signaling pathway signal transduction positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure organelle subcompartment cytoplasmic side of membrane membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane-bounded organelle intracellular anatomical structure organelle subcompartment cytoplasmic side of membrane membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane protein-containing complex membrane protein complex SREBP-SCAP complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR000731	Sterol-sensing domain	Domain
A, C [auth B], E [auth C], G [auth D]	IPR030225	Sterol regulatory element-binding protein cleavage-activating protein	Family
A, C [auth B], E [auth C], G [auth D]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B [auth I], D [auth J], F [auth K], H [auth L]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B [auth I], D [auth J], F [auth K], H [auth L]	IPR000731	Sterol-sensing domain	Domain
B [auth I], D [auth J], F [auth K], H [auth L]	IPR030225	Sterol regulatory element-binding protein cleavage-activating protein	Family
B [auth I], D [auth J], F [auth K], H [auth L]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
I [auth E], J [auth F], K [auth G], L [auth H]	IPR019006	Sterol regulatory element-binding protein 1, C-terminal	Domain
I [auth E], J [auth F], K [auth G], L [auth H]	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
I [auth E], J [auth F], K [auth G], L [auth H]	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.