Annotations: 5FRP

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF20168	e5frpA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF20168	ECOD (1.6)
B	PF20168	e5frpB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF20168	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF20168	Sister chromatid cohesion protein PDS5 protein (PDS5)	Sister chromatid cohesion protein PDS5 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	SISTER CHROMATID COHESION PROTEIN PDS5	structural molecule activity	sexual reproduction reproductive process meiotic cell cycle primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process meiotic DNA double-strand break formation organic cyclic compound metabolic process organic substance metabolic process meiosis I cell cycle process cellular process metabolic process sexual reproduction reproductive process meiotic cell cycle primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process meiotic DNA double-strand break formation organic cyclic compound metabolic process organic substance metabolic process meiosis I cell cycle process cellular process metabolic process cell cycle macromolecule metabolic process cell cycle process protein-DNA complex organization cellular component organization chromatin looping protein-containing complex organization chromatin organization cellular component organization or biogenesis cell division organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion mitotic nuclear division mitotic chromosome condensation organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation cellular response to stimulus double-strand break repair response to stimulus cellular response to stress DNA damage response response to stress DNA repair meiotic chromosome segregation chromosome organization involved in meiotic cell cycle meiosis I homologous chromosome pairing at meiosis meiotic nuclear division homologous chromosome segregation	membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle condensed chromosome non-membrane-bounded organelle nuclear lumen cytoplasm cytosol protein-containing complex protein-DNA complex chromatin meiotic recombination initiation complex nuclear protein-containing complex
C, D	MCD1-LIKE PROTEIN	protein binding binding kinase binding enzyme binding protein kinase binding protein-containing complex binding chromatin binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process replication-born double-strand break repair via sister chromatid exchange recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair protein acetylation organonitrogen compound metabolic process macromolecule modification protein metabolic process protein modification process protein acylation cell division cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle cell cycle process apoptotic process cell death programmed cell death mitotic nuclear division mitotic chromosome condensation organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular organelle lumen membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle condensed chromosome non-membrane-bounded organelle nuclear lumen chromosome, centromeric region chromosomal region protein-containing complex cohesin complex mitotic cohesin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR039776	Sister chromatid cohesion protein Pds5	Family
C, D	IPR039781	Rad21/Rec8-like protein	Family
C, D	IPR006910	Rad21/Rec8-like protein, N-terminal	Domain
C, D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C, D	IPR023093	ScpA-like, C-terminal	Homologous Superfamily
C, D	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.