5EWS

Sugar binding protein - human galectin-2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d5ewsa_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d5ewsf_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d5ewsi_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d5ewsm_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
P	d5ewsp_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth B]	d5ewsb_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5ewsc_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5ewsd_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d5ewse_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d5ewsg_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d5ewsh_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d5ewsj_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d5ewsk_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d5ewsl_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d5ewsn_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
O	d5ewso_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041399	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	PF00337	e5ewsA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
F	PF00337	e5ewsF1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
I	PF00337	e5ewsI1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
M	PF00337	e5ewsM1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
P	PF00337	e5ewsP1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
A [auth B]	PF00337	e5ewsB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
C	PF00337	e5ewsC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
D	PF00337	e5ewsD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
E	PF00337	e5ewsE1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
G	PF00337	e5ewsG1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
H	PF00337	e5ewsH1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
J	PF00337	e5ewsJ1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
K	PF00337	e5ewsK1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
L	PF00337	e5ewsL1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
N	PF00337	e5ewsN1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
O	PF00337	e5ewsO1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
F	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
I	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
M	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
P	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A [auth B]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
E	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
G	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
H	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
J	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
K	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
L	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
N	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
O	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF00337	Galactoside-binding lectin (Gal-bind_lectin)	Galactoside-binding lectin	This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H, I, J, K, L, M, N, O, P	Galectin-2	binding carbohydrate binding galactoside binding carbohydrate derivative binding	regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process multicellular organismal process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis cell adhesion cell-cell adhesion regulation of defense response response to stimulus regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response	protein complex involved in cell-cell adhesion protein-containing complex galectin complex protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR044156	Galectin-like	Family
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR001079	Galectin, carbohydrate recognition domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H, I, J, K, L, M, N, O, P	Pharos: P05162	Liver Cirrhosis, Experimental myocardial infarction perinatal necrotizing enterocolitis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer Sjogren syndrome acute myeloid leukemia chronic obstructive pulmonary disease gastric carcinoma interstitial cystitis lung cancer malignant pancreatic neoplasm nephrosclerosis pancreatic ductal adenocarcinoma Liver Cirrhosis, Experimental myocardial infarction perinatal necrotizing enterocolitis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer Sjogren syndrome acute myeloid leukemia chronic obstructive pulmonary disease gastric carcinoma interstitial cystitis lung cancer malignant pancreatic neoplasm nephrosclerosis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis tuberculosis atopic eczema cutaneous lupus erythematosus glioblastoma malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma sarcoidosis ulcerative colitis B-cell chronic lymphocytic leukemia gastric cancer head and neck cancer lung adenocarcinoma necrotizing enterocolitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.