5DT1

Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth H]d5dt1h_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth L]d5dt1l2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth L]d5dt1l1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth H]PF07654e5dt1H2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
A [auth H]PF07686e5dt1H1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
B [auth L]PF07654e5dt1L2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
B [auth L]PF07686e5dt1L1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
B [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A [auth H]VRC26.25 mAb, anti-gp120 [HIV-1], neutralizing VH-CH1 Homo sapiens (human) IGHV3-30*18, IGHV3-30-5*01, IGHJ3*01, IGHJ3*02, IGHG1*03 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_LAMBDA IMGT (202416-0)
B [auth L]VRC26.25 mAb, anti-gp120 [HIV-1], neutralizing L-LAMBDA Homo sapiens (human) IGLV1-51*02, IGLJ1*01, IGLC1*02, IGLC2*01, IGLC2*02, IGLC3*04 V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA IG FAB-GAMMA-1_LAMBDA IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A [auth H]Heavy ChainIGHV3 -polysaccharideSAbDab (2024-04-26)
B [auth L]Light ChainIGLV1 LambdapolysaccharideSAbDab (2024-04-26)

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A [auth H]TYS Parent Component: TYR

RESID:  AA0172

PSI-MOD :  O4'-sulfo-L-tyrosine MOD:00181