4WL0

Ligand-free structure of human platelet phosphofructokinase in an R-state, crystal form I

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00365	e4wl0A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PF00365	ECOD (1.6)
A	PF00365	e4wl0A2	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PF00365	ECOD (1.6)
B	PF00365	e4wl0B2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PF00365	ECOD (1.6)
B	PF00365	e4wl0B3	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PF00365	ECOD (1.6)
C	PF00365	e4wl0C3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PF00365	ECOD (1.6)
C	PF00365	e4wl0C2	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PF00365	ECOD (1.6)
D	PF00365	e4wl0D4	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PF00365	ECOD (1.6)
D	PF00365	e4wl0D1	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PF00365	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.450	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.40.50.460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphofructokinase domain	CATH (4.3.0)
B	3.40.50.450	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphofructokinase domain	CATH (4.3.0)
C	3.40.50.450	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphofructokinase domain	CATH (4.3.0)
D	3.40.50.450	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.40.50.460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphofructokinase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00365	Phosphofructokinase (PFK)	Phosphofructokinase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ATP-dependent 6-phosphofructokinase, platelet type	binding ion binding anion binding carbohydrate derivative binding fructose-6-phosphate binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding cation binding AMP binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding binding ion binding anion binding carbohydrate derivative binding fructose-6-phosphate binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding cation binding AMP binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding heterocyclic compound binding ribonucleotide binding monosaccharide binding carbohydrate binding purine ribonucleoside triphosphate binding ATP binding cell adhesion molecule binding cadherin binding protein binding protein-containing complex binding carbohydrate kinase activity kinase activity phosphofructokinase activity 6-phosphofructokinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups metal ion binding identical protein binding	organic substance metabolic process organophosphate metabolic process cellular metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process carbohydrate derivative metabolic process metabolic process cellular process phosphorus metabolic process fructose 1,6-bisphosphate metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organic substance metabolic process organophosphate metabolic process cellular metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process carbohydrate derivative metabolic process metabolic process cellular process phosphorus metabolic process fructose 1,6-bisphosphate metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process pyridine-containing compound metabolic process NADH regeneration small molecule metabolic process purine ribonucleotide catabolic process glucose catabolic process to pyruvate pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process organonitrogen compound catabolic process pyruvate metabolic process hexose catabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process hexose metabolic process nucleotide metabolic process NADH metabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process glucose catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process monosaccharide catabolic process small molecule catabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process monosaccharide metabolic process canonical glycolysis catabolic process ATP metabolic process NAD metabolic process glycolytic process through glucose-6-phosphate NAD catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process glycolytic process through fructose-6-phosphate glucose metabolic process cellular response to stimulus response to organic substance response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex 6-phosphofructokinase complex intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR041914	ATP-dependent 6-phosphofructokinase, vertebrate-type	Family
A, B, C, D	IPR009161	ATP-dependent 6-phosphofructokinase, eukaryotic-type	Family
A, B, C, D	IPR035966	Phosphofructokinase superfamily	Homologous Superfamily
A, B, C, D	IPR000023	Phosphofructokinase domain	Domain
A, B, C, D	IPR022953	ATP-dependent 6-phosphofructokinase	Family
A, B, C, D	IPR015912	Phosphofructokinase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q01813	Liver Cirrhosis, Experimental adrenal cortex carcinoma Crohn disease malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis astrocytic tumor dermatomyositis lung adenocarcinoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor large cell medulloblastoma Liver Cirrhosis, Experimental adrenal cortex carcinoma Crohn disease malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis astrocytic tumor dermatomyositis lung adenocarcinoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.