4P5X

Structure of the N-terminal domain of the human mitochondrial aspartate/glutamate carrier Aralar in the calcium-bound state

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e4p5xA3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Calcium-binding mitochondrial carrier protein Aralar1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding monoatomic cation transmembrane transporter activity L-amino acid transmembrane transporter activity proton transmembrane transporter activity sulfur amino acid transmembrane transporter activity sulfur compound transmembrane transporter activity 3-sulfino-L-alanine: proton, glutamate antiporter activity modified amino acid transmembrane transporter activity secondary active transmembrane transporter activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding monoatomic cation transmembrane transporter activity L-amino acid transmembrane transporter activity proton transmembrane transporter activity sulfur amino acid transmembrane transporter activity sulfur compound transmembrane transporter activity 3-sulfino-L-alanine: proton, glutamate antiporter activity modified amino acid transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity transporter activity sulfur-containing amino acid secondary active transmembrane transporter activity carboxylic acid transmembrane transporter activity amino acid transmembrane transporter activity active transmembrane transporter activity neutral L-amino acid transmembrane transporter activity monoatomic ion transmembrane transporter activity organic acid transmembrane transporter activity amino acid:monoatomic cation antiporter activity transmembrane transporter activity organic anion transmembrane transporter activity acidic amino acid transmembrane transporter activity L-glutamate transmembrane transporter activity C4-dicarboxylate transmembrane transporter activity aspartate:glutamate, proton antiporter activity dicarboxylic acid transmembrane transporter activity L-aspartate transmembrane transporter activity identical protein binding protein binding	organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport organic substance transport amino acid transmembrane transport L-amino acid transport establishment of localization L-glutamate import organic acid transport transmembrane transport amino acid transport localization organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport organic substance transport amino acid transmembrane transport L-amino acid transport establishment of localization L-glutamate import organic acid transport transmembrane transport amino acid transport localization acidic amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport cellular process L-glutamate transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance monosaccharide metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process primary metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process glucose metabolic process organonitrogen compound metabolic process oxoacid metabolic process cellular metabolic process aspartate family amino acid metabolic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process aspartate transmembrane transport C4-dicarboxylate transport cellular respiration energy derivation by oxidation of organic compounds electron transport chain generation of precursor metabolites and energy mitochondrial transmembrane transport respiratory electron transport chain malate-aspartate shuttle mitochondrial transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018108	Mitochondrial substrate/solute carrier	Repeat
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR002067	Mitochondrial carrier protein	Family
A	IPR023395	Mitochondrial carrier domain superfamily	Homologous Superfamily
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O75746	developmental and epileptic encephalopathy, 39 rheumatoid arthritis osteosarcoma Pick disease schizophrenia amyotrophic lateral sclerosis autism Down syndrome intellectual disability leukodystrophy malignant ependymoma medulloblastoma ovarian cancer primitive neuroectodermal tumor subependymal giant cell astrocytoma developmental and epileptic encephalopathy, 39 rheumatoid arthritis osteosarcoma Pick disease schizophrenia amyotrophic lateral sclerosis autism Down syndrome intellectual disability leukodystrophy malignant ependymoma medulloblastoma ovarian cancer primitive neuroectodermal tumor subependymal giant cell astrocytoma astrocytic tumor Autistic Disorder juvenile dermatomyositis lung cancer malignant glioma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma lung carcinoma malignant mesothelioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.