Annotations: 4OMT

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PFK_N	e4omtA3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PFK_N	ECOD (1.6)
A	PFK_C	e4omtA4	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PFK_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00365	Phosphofructokinase (PFK)	Phosphofructokinase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	6-phosphofructokinase, muscle type	binding monosaccharide binding fructose binding carbohydrate binding small molecule binding ion binding anion binding carbohydrate derivative binding fructose-6-phosphate binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding cation binding AMP binding binding monosaccharide binding fructose binding carbohydrate binding small molecule binding ion binding anion binding carbohydrate derivative binding fructose-6-phosphate binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding cation binding AMP binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding heterocyclic compound binding ribonucleotide binding purine ribonucleoside triphosphate binding ATP binding protein binding kinase binding enzyme binding carbohydrate kinase activity kinase activity phosphofructokinase activity 6-phosphofructokinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups metal ion binding identical protein binding	organic substance metabolic process organophosphate metabolic process cellular metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process carbohydrate derivative metabolic process metabolic process cellular process phosphorus metabolic process glycolytic process through glucose-1-phosphate ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organic substance metabolic process organophosphate metabolic process cellular metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process carbohydrate derivative metabolic process metabolic process cellular process phosphorus metabolic process glycolytic process through glucose-1-phosphate ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process polysaccharide catabolic process nucleoside diphosphate catabolic process macromolecule metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process glycolytic process through glucose-6-phosphate macromolecule catabolic process polysaccharide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy organic cyclic compound catabolic process glycolysis from storage polysaccharide through glucose-1-phosphate purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process glycolytic process through fructose-6-phosphate glucan catabolic process energy derivation by oxidation of organic compounds glycogen metabolic process glucan metabolic process glycogen catabolic process energy reserve metabolic process fructose 1,6-bisphosphate metabolic process NADH regeneration glucose catabolic process to pyruvate hexose catabolic process hexose metabolic process NADH metabolic process glucose catabolic process monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process canonical glycolysis NAD metabolic process NAD catabolic process glucose metabolic process protein localization positive regulation of cell communication regulation of localization establishment of protein localization nitrogen compound transport regulation of cellular process positive regulation of establishment of protein localization cell communication localization cellular macromolecule localization positive regulation of insulin secretion regulation of biological quality regulation of peptide hormone secretion regulation of biological process regulation of hormone levels organic substance transport positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion positive regulation of protein localization cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport signaling positive regulation of biological process positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of cellular process positive regulation of peptide secretion regulation of signaling secretion regulation of transport regulation of peptide transport biological regulation regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport positive regulation of protein secretion peptide transport positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion positive regulation of signaling positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis cellular homeostasis muscle cell cellular homeostasis	membrane cellular anatomical entity cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle cell projection sperm principal piece organelle membrane cellular anatomical entity cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle cell projection sperm principal piece organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex 6-phosphofructokinase complex intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041914	ATP-dependent 6-phosphofructokinase, vertebrate-type	Family
A	IPR009161	ATP-dependent 6-phosphofructokinase, eukaryotic-type	Family
A	IPR035966	Phosphofructokinase superfamily	Homologous Superfamily
A	IPR000023	Phosphofructokinase domain	Domain
A	IPR022953	ATP-dependent 6-phosphofructokinase	Family
A	IPR015912	Phosphofructokinase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08237	glycogen storage disease VII Diabetes Mellitus, Experimental glycogen storage disease prostate carcinoma acute myeloid leukemia congenital anemia lung cancer medulloblastoma pancreatic ductal adenocarcinoma rhabdomyolysis coronary artery disease inborn errors of metabolism malignant mesothelioma myocardial ischemia plasma cell myeloma glycogen storage disease VII Diabetes Mellitus, Experimental glycogen storage disease prostate carcinoma acute myeloid leukemia congenital anemia lung cancer medulloblastoma pancreatic ductal adenocarcinoma rhabdomyolysis coronary artery disease inborn errors of metabolism malignant mesothelioma myocardial ischemia plasma cell myeloma arthrogryposis malignant pancreatic neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.