4O9B

The Structure of CC1-IH in human STIM1.

External Resource: Annotation

Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Stromal interaction molecule 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding enzyme binding protease binding channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding enzyme binding protease binding channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity cytoskeletal protein binding microtubule plus-end binding microtubule binding tubulin binding identical protein binding	localization store-operated calcium entry transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport regulation of calcium ion transport regulation of localization regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation localization store-operated calcium entry transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport regulation of calcium ion transport regulation of localization regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation regulation of metal ion transport developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development anatomical structure morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity regulation of store-operated calcium entry multicellular organismal process regulation of developmental process positive regulation of biological process angiogenesis regulation of vasculature development positive regulation of developmental process multicellular organism development tube morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process regulation of calcium ion transmembrane transporter activity positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process activation of store-operated calcium channel activity regulation of store-operated calcium channel activity positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport positive regulation of store-operated calcium channel activity inorganic ion transmembrane transport positive regulation of cation channel activity regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport monoatomic ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport regulation of calcium ion transmembrane transport positive regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of cellular process regulation of monoatomic ion transmembrane transporter activity positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity cellular process regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport detection of stimulus response to stimulus response to metal ion response to chemical detection of chemical stimulus detection of calcium ion response to calcium ion response to inorganic substance	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane cell periphery plasma membrane cell cortex cortical endoplasmic reticulum endoplasmic reticulum tubular network membrane microdomain membrane raft plasma membrane raft plasma membrane region polymeric cytoskeletal fiber cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037609	Stromal interaction molecule 1, SAM domain	Domain
A, B, C, D	IPR037608	Stromal interaction molecule	Family
A, B, C, D	IPR032393	Stromal interaction molecule, Orai1-activating region	Domain
A, B, C, D	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B, C, D	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q13586	Stormorken syndrome combined immunodeficiency due to STIM1 deficiency myopathy, tubular aggregate, 1 tubular aggregate myopathy centronuclear myopathy hypertensive disorder juvenile idiopathic arthritis Neoplasms, Experimental congenital structural myopathy psoriasis amelogenesis imperfecta autosomal dominant centronuclear myopathy congenital fiber-type disproportion myopathy large cell medulloblastoma X-linked centronuclear myopathy Stormorken syndrome combined immunodeficiency due to STIM1 deficiency myopathy, tubular aggregate, 1 tubular aggregate myopathy centronuclear myopathy hypertensive disorder juvenile idiopathic arthritis Neoplasms, Experimental congenital structural myopathy psoriasis amelogenesis imperfecta autosomal dominant centronuclear myopathy congenital fiber-type disproportion myopathy large cell medulloblastoma X-linked centronuclear myopathy arthrogryposis lung benign neoplasm medulloblastoma osteosarcoma transient myeloproliferative syndrome attention deficit hyperactivity disorder, inattentive type autosomal recessive centronuclear myopathy conduct disorder

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.