4NHF

Crystal structure of the soluble domain of TrwG Type IV secretion machinery from Bartonella grahamii

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4nhfa_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Bartonella grahamii as4aup ) [TaxId: 634504 ],	SCOPe (2.08)
B	d4nhfb_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Bartonella grahamii as4aup ) [TaxId: 634504 ],	SCOPe (2.08)
C	d4nhfc_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Bartonella grahamii as4aup ) [TaxId: 634504 ],	SCOPe (2.08)
D	d4nhfd_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Bartonella grahamii as4aup ) [TaxId: 634504 ],	SCOPe (2.08)
E	d4nhfe_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Bartonella grahamii as4aup ) [TaxId: 634504 ],	SCOPe (2.08)
F	d4nhff_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Bartonella grahamii as4aup ) [TaxId: 634504 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NTF2-like	8078091	3000472	SCOP2B (2022-06-29)
B	SCOP2 Family	VirB8-like	8078090	4001668	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	NTF2-like	8078091	3000472	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8078091	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8078091	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8078091	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8078091	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04335	e4nhfA1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF04335	ECOD (1.6)
B	PF04335	e4nhfB1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF04335	ECOD (1.6)
C	PF04335	e4nhfC1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF04335	ECOD (1.6)
D	PF04335	e4nhfD1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF04335	ECOD (1.6)
E	PF04335	e4nhfE1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF04335	ECOD (1.6)
F	PF04335	e4nhfF1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF04335	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.230	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.450.230	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.230	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.230	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E	3.10.450.230	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.230	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF04335	VirB8 protein (VirB8)	VirB8 protein	VirB8 is a bacterial virulence protein with cytoplasmic, transmembrane, and periplasmic regions. It is thought that it is a primary constituent of a DNA transporter. The periplasmic region interacts with VirB9, VirB10, and itself [1]. This family als ...	VirB8 is a bacterial virulence protein with cytoplasmic, transmembrane, and periplasmic regions. It is thought that it is a primary constituent of a DNA transporter. The periplasmic region interacts with VirB9, VirB10, and itself [1]. This family also includes the conjugal transfer protein family TrbF, a family of proteins known to be involved in conjugal transfer. The TrbF protein is thought to compose part of the pilus required for transfer [2]. This domain has a similar fold to the NTF2 protein.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	TrwG protein	cation binding ion binding binding metal ion binding small molecule binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization secretion by cell protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport protein secretion by the type IV secretion system cellular macromolecule localization macromolecule localization cellular process secretion by the type IV secretion system	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR007430	Bacterial virulence protein VirB8	Domain
A, B, C, D, E A, B, C, D, E, F	IPR026264	Type IV secretion system protein VirB8/PtlE	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.