4M4X

Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAS_1	e4m4xA1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_1	ECOD (1.6)
B	PAS_1	e4m4xB1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
B	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Aryl hydrocarbon receptor	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen arachidonic acid omega-hydroxylase activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen arachidonic acid omega-hydroxylase activity catalytic activity sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding protein-folding chaperone binding RNA polymerase II-specific DNA-binding transcription factor binding signaling receptor binding DNA-binding transcription factor binding aryl hydrocarbon receptor binding sequence-specific double-stranded DNA binding double-stranded DNA binding transcription regulator activity DNA-binding transcription factor activity identical protein binding protein homodimerization activity protein dimerization activity transcription coregulator binding transcription coactivator binding E-box binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding toxic substance binding DNA-binding transcription factor activity, RNA polymerase II-specific TBP-class protein binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity Hsp90 protein binding heat shock protein binding protein heterodimerization activity	response to stimulus response to chemical response to xenobiotic stimulus developmental process heart development multicellular organismal process heart growth regulation of biological process regulation of growth regulation of multicellular organismal development regulation of developmental growth regulation of developmental process developmental growth animal organ development response to stimulus response to chemical response to xenobiotic stimulus developmental process heart development multicellular organismal process heart growth regulation of biological process regulation of growth regulation of multicellular organismal development regulation of developmental growth regulation of developmental process developmental growth animal organ development growth biological regulation organ growth circulatory system development multicellular organism development regulation of organ growth regulation of heart growth anatomical structure development regulation of multicellular organismal process system development regulation of tube diameter system process regulation of tube size regulation of system process negative regulation of biological process negative regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction blood vessel diameter maintenance regulation of biological quality negative regulation of multicellular organismal process vasoconstriction blood circulation regulation of anatomical structure size regulation of adaptive immune response immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process adaptive immune response regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly organic substance metabolic process positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis response to toxic substance rhythmic process circadian regulation of gene expression circadian rhythm immune system development spleen development hematopoietic or lymphoid organ development branching morphogenesis of an epithelial tube angiogenesis tube morphogenesis epithelial tube morphogenesis blood vessel development epithelium development blood vessel morphogenesis tube development morphogenesis of an epithelium tissue development vasculature development branching involved in blood vessel morphogenesis anatomical structure morphogenesis tissue morphogenesis morphogenesis of a branching structure anatomical structure formation involved in morphogenesis morphogenesis of a branching epithelium cell morphogenesis cellular response to stimulus cellular response to chemical stimulus cellular response to toxic substance adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity regulation of response to biotic stimulus negative regulation of response to biotic stimulus immune response to tumor cell negative regulation of immune response to tumor cell negative regulation of response to tumor cell negative regulation of lymphocyte mediated immunity regulation of response to tumor cell response to biotic stimulus T cell mediated immune response to tumor cell negative regulation of T cell mediated immune response to tumor cell regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated immune response to tumor cell leukocyte mediated immunity regulation of T cell mediated immunity response to tumor cell negative regulation of response to stimulus negative regulation of immune response negative regulation of immune effector process regulation of immune response to tumor cell negative regulation of adaptive immune response immune effector process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity negative regulation of immune system process negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity signaling intracellular signal transduction cell communication cAMP-mediated signaling intracellular signaling cassette signal transduction negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process response to organic substance cellular response to organic cyclic compound response to polycyclic arene cellular response to 3-methylcholanthrene response to 3-methylcholanthrene cellular response to polycyclic arene cellular response to organic substance response to organic cyclic compound response to 2,3,7,8-tetrachlorodibenzodioxine cellular response to 2,3,7,8-tetrachlorodibenzodioxine regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response cell cycle cellular response to xenobiotic stimulus xenobiotic metabolic process renal system development glomerulus development glomerulus morphogenesis nephron development kidney development regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation B cell activation cell activation B cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of systemic arterial blood pressure regulation of blood pressure negative regulation of systemic arterial blood pressure negative regulation of blood pressure positive regulation of cell size regulation of cellular component size regulation of cell size icosanoid metabolic process fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process organic acid metabolic process arachidonic acid metabolic process cellular lipid metabolic process omega-hydroxylase P450 pathway olefinic compound metabolic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process response to ketone response to lipid response to alcohol cellular response to forskolin response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to alcohol response to forskolin cellular response to lipid cellular response to ketone reproductive system development prostate gland development reproductive process gland development urogenital system development developmental process involved in reproduction reproductive structure development regulation of calcium ion transport regulation of localization transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of transport regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization negative regulation of monoatomic ion transmembrane transport monoatomic ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport negative regulation of calcium ion transport transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport negative regulation of calcium ion transmembrane transport calcium ion transmembrane transport positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of growth positive regulation of growth rate regulation of growth rate gonad development female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics development of primary sexual characteristics ovarian follicle development negative regulation of cell population proliferation osteoblast proliferation negative regulation of osteoblast proliferation regulation of osteoblast proliferation reactive oxygen species biosynthetic process reactive oxygen species metabolic process hepaticobiliary system development liver development cellular developmental process hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation B cell differentiation cell differentiation leukocyte differentiation sensory organ development eye development visual system development camera-type eye development sensory system development regulation of DNA biosynthetic process DNA metabolic process negative regulation of DNA metabolic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of osteoblast differentiation negative regulation of osteoblast differentiation negative regulation of developmental process regulation of cell differentiation osteoblast differentiation ossification negative regulation of cell differentiation T cell homeostasis heart morphogenesis cardiac chamber development animal organ morphogenesis cardiac chamber morphogenesis circumferential growth involved in left ventricle morphogenesis developmental growth involved in morphogenesis cardiac ventricle morphogenesis cardiac left ventricle morphogenesis cardiac ventricle development growth involved in heart morphogenesis cellular response to nitrogen compound response to organonitrogen compound response to endogenous stimulus response to organophosphorus response to nitrogen compound response to purine-containing compound response to cAMP cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to cAMP biological process involved in interspecies interaction between organisms response to other organism cellular response to molecule of bacterial origin cellular response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin blood vessel remodeling tissue remodeling post-embryonic development post-embryonic hemopoiesis B-1 B cell homeostasis kidney morphogenesis protein localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex aryl hydrocarbon receptor complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle receptor complex nuclear aryl hydrocarbon receptor complex intracellular organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex aryl hydrocarbon receptor complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle receptor complex nuclear aryl hydrocarbon receptor complex intracellular organelle organelle intracellular protein-containing complex transcription regulator complex cytosolic aryl hydrocarbon receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013655	PAS fold-3	Domain
A, B	IPR039091	Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor	Family
A, B	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B	IPR000014	PAS domain	Domain
A, B	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A, B	IPR001610	PAC motif	Repeat
A, B	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR033348	Aryl hydrocarbon receptor, basic helix-loop-helix domain	Domain
A, B	IPR013767	PAS fold	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.