Annotations: 4LNZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4lnza_	All alpha proteins	alpha-alpha superhelix	DIL domain-like	DIL domains from class V myosins	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DIL	e4lnzA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: DIL	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Unconventional myosin-Vb	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding cytoskeletal motor activity microfilament motor activity ATP-dependent activity	protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process establishment of localization in cell intracellular transport protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process establishment of localization in cell intracellular transport vesicle-mediated transport endosomal transport vesicle transport along actin filament vesicle cytoskeletal trafficking vesicle localization establishment of organelle localization establishment of vesicle localization actin filament-based movement organelle localization actin filament-based process cytoskeleton-dependent intracellular transport actin filament-based transport cellular component organization organelle organization actin cytoskeleton organization actin filament organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization regulation of body fluid levels multicellular organismal process renal system process system process homeostatic process biological regulation multicellular organismal-level homeostasis chemical homeostasis multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis renal water homeostasis regulation of biological quality	membrane-bounded organelle organelle cellular anatomical entity vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle membrane-bounded organelle organelle cellular anatomical entity vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm protein-containing complex myosin complex membrane intracellular vesicle intracellular membrane-bounded organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle organelle membrane cell periphery cell cortex apical part of cell cell cortex region cytoplasmic region apical cortex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR002710	Dilute domain	Domain
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR036103	Class V myosin, motor domain	Domain
A	IPR037990	Myosin 5b, cargo-binding domain	Domain
A	IPR001609	Myosin head, motor domain	Domain
A	IPR004009	Myosin, N-terminal, SH3-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9ULV0	microvillus inclusion disease amphetamine abuse liver cancer inborn errors of metabolism intestinal disease pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor bowel dysfunction diarrheal disease intellectual disability Intestinal Diseases medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive familial intrahepatic cholestasis microvillus inclusion disease amphetamine abuse liver cancer inborn errors of metabolism intestinal disease pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor bowel dysfunction diarrheal disease intellectual disability Intestinal Diseases medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive familial intrahepatic cholestasis ductal breast carcinoma in situ interstitial cystitis ovarian cancer pituitary cancer schizophrenia liver neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.