3W12
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth E] | SCOP2B Superfamily | Growth factor receptor domain-like | 8032837 | 3000398 | SCOP2B (2022-06-29) |
A [auth E] | SCOP2B Superfamily | L domain-like | 8032830 | 3001010 | SCOP2B (2022-06-29) |
D [auth A] | SCOP2B Superfamily | Insulin-like | 8038024 | 3000307 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth E] | PF01030 | e3w12E3 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF01030 | ECOD (1.6) |
A [auth E] | PF00757 | e3w12E4 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: PF00757 | ECOD (1.6) |
B [auth C] | PF07686 | e3w12C1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
C [auth D] | PF07686 | e3w12D1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
B [auth C] | Fab 83-7 | VH | Mus musculus (house mouse) | IGHV2-6-7*01, IGHV2-6-7*02, IGHJ4*01 | V-DOMAIN VH | IG | FV-HEAVY_KAPPA | IMGT (202421-0) |
C [auth D] | Fab 83-7 | V-KAPPA | Mus musculus (house mouse) | IGKV8-30*01, IGKJ1*01, IGKJ1*02, IGKJ2*01 | V-DOMAIN V-KAPPA | IG | FV-HEAVY_KAPPA | IMGT (202421-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
B [auth C] | Heavy Chain | IGHV2 | - | insulin receptor domains l1-cr | SAbDab (2024-05-31) |
C [auth D] | Light Chain | IGKV8 | Kappa | insulin receptor domains l1-cr | SAbDab (2024-05-31) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth E] | PF00757 | Furin-like cysteine rich region (Furin-like) | Furin-like cysteine rich region | - | Domain |
A [auth E] | PF01030 | Receptor L domain (Recep_L_domain) | Receptor L domain | - | Repeat |
D [auth A] | PF00049 | Insulin/IGF/Relaxin family (Insulin) | Insulin/IGF/Relaxin family | Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. | Domain |
E [auth B] | PF00049 | Insulin/IGF/Relaxin family (Insulin) | Insulin/IGF/Relaxin family | Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. | Domain |