Annotations: 3TER

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SOAR domain-like	8045729	4004644	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SOAR domain-like	8090886	3002466	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	SOAR domain-like	8090886	3002466	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.3550	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B	1.10.287.3550	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16533	STIM1 Orai1-activating region (SOAR)	STIM1 Orai1-activating region	SOAR is the Orai1-activating region of STIM1, where STIM1 are calcium sensors in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma ...	SOAR is the Orai1-activating region of STIM1, where STIM1 are calcium sensors in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region, which runs from residues 340-443 on UniProtKB:Q13586, forms a dimer, and is essential for oligomerisation of the whole of STIM1 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Mammalian stromal interaction molecule-1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity identical protein binding protein binding	localization store-operated calcium entry transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport multicellular organismal process system process regulation of biological process positive regulation of smooth muscle contraction regulation of system process biological regulation localization store-operated calcium entry transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport multicellular organismal process system process regulation of biological process positive regulation of smooth muscle contraction regulation of system process biological regulation positive regulation of biological process muscle contraction muscle system process regulation of muscle system process smooth muscle contraction regulation of muscle contraction regulation of smooth muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process regulation of multicellular organismal process ovulation sexual reproduction reproductive process multicellular organismal reproductive process female gamete generation gamete generation inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis import into cell regulation of localization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of membrane invagination positive regulation of apoptotic cell clearance vesicle-mediated transport cellular component organization engulfment of apoptotic cell positive regulation of endocytosis positive regulation of engulfment of apoptotic cell regulation of phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis apoptotic cell clearance plasma membrane invagination positive regulation of cellular process regulation of endocytosis membrane organization regulation of engulfment of apoptotic cell regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport phagocytosis, engulfment positive regulation of phagocytosis positive regulation of transport positive regulation of phagocytosis, engulfment cellular process regulation of membrane invagination endocytosis regulation of apoptotic cell clearance	intracellular organelle intracellular anatomical structure organelle cellular anatomical entity somatodendritic compartment cell body neuronal cell body cell periphery plasma membrane membrane cell projection dendrite dendritic tree neuron projection intracellular organelle intracellular anatomical structure organelle cellular anatomical entity somatodendritic compartment cell body neuronal cell body cell periphery plasma membrane membrane cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cytoplasm membrane-bounded organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B	IPR037608	Stromal interaction molecule	Family
A, B	IPR001660	Sterile alpha motif domain	Domain
A, B	IPR032393	Stromal interaction molecule, Orai1-activating region	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.