3L4G

Crystal structure of Homo Sapiens cytoplasmic Phenylalanyl-tRNA synthetase

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG2784_1st	e3l4gA3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG2784_1st	ECOD (1.6)
A	tRNA-synt_2d	e3l4gA1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
C	KOG2784_like	e3l4gC2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: KOG2784_like	ECOD (1.6)
C	KOG2784_2nd	e3l4gC3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG2784_2nd	ECOD (1.6)
C	KOG2784_1st	e3l4gC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG2784_1st	ECOD (1.6)
C	tRNA-synt_2d	e3l4gC4	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
E	tRNA-synt_2d	e3l4gE1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
G	tRNA-synt_2d	e3l4gG1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
I	KOG2784_1st	e3l4gI2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG2784_1st	ECOD (1.6)
I	tRNA-synt_2d	e3l4gI1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
K	KOG2784_1st	e3l4gK2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG2784_1st	ECOD (1.6)
K	tRNA-synt_2d	e3l4gK1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
M	KOG2784_1st	e3l4gM2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG2784_1st	ECOD (1.6)
M	tRNA-synt_2d	e3l4gM1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
O	tRNA-synt_2d	e3l4gO1	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d	ECOD (1.6)
B	B3_4	e3l4gB4	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
B	B5	e3l4gB2	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
B	PLN02265	e3l4gB12	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
B	tRNA-synt_2d_1	e3l4gB10	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
D	B3_4	e3l4gD15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
D	B5	e3l4gD13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
D	PLN02265	e3l4gD16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
D	tRNA-synt_2d_1	e3l4gD14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
H	B3_4	e3l4gH15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
H	B5	e3l4gH13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
H	PLN02265	e3l4gH16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
H	tRNA-synt_2d_1	e3l4gH14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
J	B3_4	e3l4gJ15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
J	B5	e3l4gJ13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
J	PLN02265	e3l4gJ16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
J	tRNA-synt_2d_1	e3l4gJ14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
L	B3_4	e3l4gL15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
L	B5	e3l4gL13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
L	PLN02265	e3l4gL16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
L	tRNA-synt_2d_1	e3l4gL14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
N	B3_4	e3l4gN15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
N	B5	e3l4gN13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
N	PLN02265	e3l4gN16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
N	tRNA-synt_2d_1	e3l4gN14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
P	B3_4	e3l4gP15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
P	B5	e3l4gP13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
P	PLN02265	e3l4gP16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
P	tRNA-synt_2d_1	e3l4gP14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)
F	B3_4	e3l4gF15	A: beta complex topology	X: PheT/TilS domain (From Topology)	H: PheT/TilS domain (From Topology)	T: PheT/TilS domain	F: B3_4	ECOD (1.6)
F	B5	e3l4gF13	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: B5	ECOD (1.6)
F	PLN02265	e3l4gF16	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PLN02265	ECOD (1.6)
F	tRNA-synt_2d_1	e3l4gF14	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: tRNA-synt_2d_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
C	3.30.1370.240	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
C	1.10.10.2320	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
C	1.10.10.2330	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
C	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
E	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
G	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
I	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
K	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
M	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
O	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
B	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
B	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
B	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
D	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
D	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
D	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
H	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
H	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
H	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
J	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
J	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
J	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
L	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
L	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
L	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
N	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
N	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
N	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
P	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
P	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
P	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)
F	3.30.56.10	Alpha Beta	2-Layer Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 1	CATH (4.3.0)
F	3.50.40.10	Alpha Beta	3-Layer(bba) Sandwich	Phenylalanyl-tRNA Synthetase	Chain B, domain 3	CATH (4.3.0)
F	3.30.930.10	Alpha Beta	2-Layer Sandwich	BirA Bifunctional Protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M, O	PF18553	PheRS DNA binding domain 3 (PheRS_DBD3)	PheRS DNA binding domain 3	This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase N-terminal region. This domain belongs to a superfamily of 'winged helix' DNA-biding domains. The topology of DBD-1 and DBD-3 closely resembles the topology of the Z-DNA-binding ...	This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase N-terminal region. This domain belongs to a superfamily of 'winged helix' DNA-biding domains. The topology of DBD-1 and DBD-3 closely resembles the topology of the Z-DNA-binding domain Zalpha of double-stranded RNA (dsRNA) adenosine deaminase and other domains from DNA-binding proteins. Mutational analysis indicate that DBD-1, 2 and 3 play critical roles in tRNAPhe binding and recognition, i.e., from the drastic reduction of aminoacylation activity seen upon removal of the N-terminal domains [1].	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	PF18554	PheRS DNA binding domain 2 (PheRS_DBD2)	PheRS DNA binding domain 2	This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase N-terminal region. Mutational analysis indicate that DBD-1, 2 and 3 play critical roles in tRNA- Phe binding and recognition, i.e., from the drastic reduction of aminoacylation a ...	This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase N-terminal region. Mutational analysis indicate that DBD-1, 2 and 3 play critical roles in tRNA- Phe binding and recognition, i.e., from the drastic reduction of aminoacylation activity seen upon removal of the N-terminal domains. DBD-2 and DBD-3 constitute large insertions sequentially included between two neighboring antiparallel strands of the DBD-1 domain. Moreover, the DBD-3 Pfam:PF18553 is the domain insertion into DBD-2 [1].	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	PF18552	PheRS DNA binding domain 1 (PheRS_DBD1)	PheRS DNA binding domain 1	This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase (EC:6.1.1.20) N-terminal region. This domain belongs to a superfamily of 'winged helix' DNA-biding domains. The topology of DBD-1 and DBD-3 closely resembles the topology of the ...	This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase (EC:6.1.1.20) N-terminal region. This domain belongs to a superfamily of 'winged helix' DNA-biding domains. The topology of DBD-1 and DBD-3 closely resembles the topology of the Z-DNA-binding domain Zalpha of double-stranded RNA (dsRNA) adenosine deaminase and other domains from DNA-binding proteins. Mutational analysis indicate that DBD-1, 2 and 3 play critical roles in tRNA-Phe binding and recognition, i.e., from the drastic reduction of aminoacylation activity seen upon removal of the N-terminal domains [1].	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	PF01409	tRNA synthetases class II core domain (F) (tRNA-synt_2d)	tRNA synthetases class II core domain (F)	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	PF18262	Phe-tRNA synthetase beta subunit B1 domain (PhetRS_B1)	Phe-tRNA synthetase beta subunit B1 domain	This is the N-terminal domain found in human cytosolic phenylalanyl tRNA synthetase beta subunit [1].	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	PF03483	B3/4 domain (B3_4)	B3/4 domain	This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	PF03484	tRNA synthetase B5 domain (B5)	tRNA synthetase B5 domain	This domain is found in phenylalanine-tRNA synthetase beta subunits.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	PF17759	Phenylalanyl tRNA synthetase beta chain CLM domain (tRNA_synthFbeta)	Phenylalanyl tRNA synthetase beta chain CLM domain	This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O	Phenylalanyl-tRNA synthetase alpha chain	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid phenylalanine-tRNA ligase activity catalytic activity, acting on a tRNA catalytic activity ligase activity RNA binding nucleic acid binding tRNA binding	protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization amino acid activation tRNA aminoacylation cellular biosynthetic process protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process metabolic process macromolecule metabolic process phenylalanyl-tRNA aminoacylation	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex phenylalanine-tRNA ligase complex
B, D, F, H, J B, D, F, H, J, L, N, P	Phenylalanyl-tRNA synthetase beta chain	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid phenylalanine-tRNA ligase activity catalytic activity, acting on a tRNA catalytic activity ligase activity RNA binding nucleic acid binding	protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization amino acid activation tRNA aminoacylation cellular biosynthetic process protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process metabolic process macromolecule metabolic process phenylalanyl-tRNA aminoacylation	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex phenylalanine-tRNA ligase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O	IPR040586	PheRS DNA binding domain 2	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O	IPR002319	Phenylalanyl-tRNA synthetase	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	IPR040724	PheRS, DNA binding domain 1	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O	IPR004529	Phenylalanyl-tRNA synthetase, class IIc, alpha subunit	Family
A, C, E, G, I A, C, E, G, I, K, M, O	IPR006195	Aminoacyl-tRNA synthetase, class II	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	IPR040725	PheRS, DNA binding domain 3	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR009061	Putative DNA-binding domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR045060	Phenylalanine-tRNA ligase, class IIc, beta subunit	Family
B, D, F, H, J B, D, F, H, J, L, N, P	IPR020825	Phenylalanyl-tRNA synthetase-like, B3/B4	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR004531	Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archaeal/eukaryotic type	Family
B, D, F, H, J B, D, F, H, J, L, N, P	IPR005147	tRNA synthetase, B5-domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR005146	B3/B4 tRNA-binding domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR041616	Phenylalanyl tRNA synthetase beta chain, core domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR040659	Phenylalanine--tRNA ligase beta subunit, B1 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G, I A, C, E, G, I, K, M, O	Pharos: Q9Y285	malignant colon neoplasm subependymal giant cell astrocytoma osteosarcoma tuberculosis psoriasis
B, D, F, H, J B, D, F, H, J, L, N, P	Pharos: Q9NSD9	Rajab interstitial lung disease with brain calcifications 1 acute myeloid leukemia primitive neuroectodermal tumor neurodegenerative disease Pick disease Sjogren syndrome