Annotations: 3KZY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3kzya2	All alpha proteins	DNA/RNA-binding 3-helical bundle	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3kzya1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Methylated DNA-protein cysteine methyltransferase domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3kzyb2	All alpha proteins	DNA/RNA-binding 3-helical bundle	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3kzyb1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Methylated DNA-protein cysteine methyltransferase domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01035	e3kzyA4	A: alpha arrays	X: HTH	H: HTH	T: Methylated DNA-protein cysteine methyltransferase-C	F: PF01035	ECOD (1.6)
A	PF02870	e3kzyA3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Methylated DNA-protein cysteine methyltransferase domain (From Topology)	T: Methylated DNA-protein cysteine methyltransferase domain	F: PF02870	ECOD (1.6)
B	PF01035	e3kzyB4	A: alpha arrays	X: HTH	H: HTH	T: Methylated DNA-protein cysteine methyltransferase-C	F: PF01035	ECOD (1.6)
B	PF02870	e3kzyB3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Methylated DNA-protein cysteine methyltransferase domain (From Topology)	T: Methylated DNA-protein cysteine methyltransferase domain	F: PF02870	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.160.70	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Methylated DNA-protein cysteine methyltransferase domain	CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B	3.30.160.70	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Methylated DNA-protein cysteine methyltransferase domain	CATH (4.3.0)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02870	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain (Methyltransf_1N)	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain	This entry represents the N-terminal ribonuclease-like domain associated with 6-O-methylguanine DNA methyltransferase activity. The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (also known ...	This entry represents the N-terminal ribonuclease-like domain associated with 6-O-methylguanine DNA methyltransferase activity. The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (also known as O-6-methylguanine-DNA-alkyltransferase)	Domain
A, B	PF01035	6-O-methylguanine DNA methyltransferase, DNA binding domain (DNA_binding_1)	6-O-methylguanine DNA methyltransferase, DNA binding domain	This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Methylated-DNA--protein-cysteine methyltransferase	DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups S-methyltransferase activity protein methyltransferase activity methylated-DNA-[protein]-cysteine S-methyltransferase activity transferase activity methyltransferase activity catalytic activity cation binding ion binding DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups S-methyltransferase activity protein methyltransferase activity methylated-DNA-[protein]-cysteine S-methyltransferase activity transferase activity methyltransferase activity catalytic activity cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair DNA modification macromolecule modification methylation	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008332	Methylguanine DNA methyltransferase, ribonuclease-like domain	Domain
A, B	IPR036217	Methylated DNA-protein cysteine methyltransferase, DNA binding domain	Homologous Superfamily
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036631	Methylated DNA-protein cysteine methyltransferase domain superfamily	Homologous Superfamily
A, B	IPR014048	Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding	Domain
A, B	IPR001497	Methylated-DNA-[protein]-cysteine S-methyltransferase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.