1ZY9

Crystal structure of Alpha-galactosidase (EC 3.2.1.22) (Melibiase) (tm1192) from Thermotoga maritima at 2.34 A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zy9a1	All beta proteins	Supersandwich	Galactose mutarotase-like	Glycosyl hydrolase family 31, N-terminal domain-like	Alpha-galactosidase GalA N-terminal domain	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
A	d1zy9a2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	Glycosyl hydrolase family 31 catalytic domain	Alpha-galactosidase GalA catalytic domain	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
A	d1zy9a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	YicI N-terminal domain-like	8024016	4003123	SCOP2 (2022-06-29)
A	SCOP2 Family	YicI catalytic domain-like	8024018	4003298	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Galactose mutarotase-like	8036395	3000035	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	(Trans)glycosidases	8036397	3000313	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22676	e1zy9A1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: PF22676	ECOD (1.6)
A	PF02065	e1zy9A2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF02065	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	2.60.40.2760	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02065	Melibiase (Melibiase)	Melibiase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	alpha-galactosidase	binding carbohydrate binding alpha-galactosidase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity galactosidase activity identical protein binding protein binding protein homodimerization activity protein dimerization activity	glycoside catabolic process carbohydrate derivative catabolic process glycosyl compound metabolic process organic substance metabolic process catabolic process glycoside metabolic process carbohydrate derivative metabolic process metabolic process glycosyl compound catabolic process organic substance catabolic process carbohydrate metabolic process primary metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A	IPR011013	Galactose mutarotase-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.