1R7M

The homing endonuclease I-SceI bound to its DNA recognition region

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d1r7ma1	Alpha and beta proteins (a+b)	Homing endonuclease-like	Homing endonucleases	Group I mobile intron endonuclease	DNA endonuclease I-SceI	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F [auth B]	d1r7mb1	Alpha and beta proteins (a+b)	Homing endonuclease-like	Homing endonucleases	Group I mobile intron endonuclease	DNA endonuclease I-SceI	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2 Family	Group I mobile intron endonuclease	8029814	4001698	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Family	Group I mobile intron endonuclease	8029815	4001698	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Homing endonucleases	8042193	3000266	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Homing endonucleases	8042194	3000266	SCOP2 (2022-06-29)
F [auth B]	SCOP2B Superfamily	Homing endonucleases	8042193	3000266	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Homing endonucleases	8042194	3000266	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	PF03161	e1r7mA2	A: a+b two layers	X: Homing endonucleases-like	H: Homing endonucleases (From Topology)	T: Homing endonucleases	F: PF03161	ECOD (1.6)
F [auth B]	PF03161	e1r7mB2	A: a+b two layers	X: Homing endonucleases-like	H: Homing endonucleases (From Topology)	T: Homing endonucleases	F: PF03161	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	3.10.28.10	Alpha Beta	Roll	Endonuclease I-creI	Homing endonucleases	CATH (4.3.0)
F [auth B]	3.10.28.10	Alpha Beta	Roll	Endonuclease I-creI	Homing endonucleases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B]	PF03161	LAGLIDADG DNA endonuclease family (LAGLIDADG_2)	LAGLIDADG DNA endonuclease family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], C [auth E]	5'-D(CPAPCPGPCPTPAPGPGPGPAPTPAPAPCPAPGPGPGPTPAPAPTPAP*C)-3'	-	-	-
B [auth D], D [auth F]	5'-D(GPGPTPAPTPTPAPCPCPCPTPGPTPTPAPTPCPCPCPTPAPGPCPGP*T)-3'	-	-	-
E [auth A], F [auth B]	Intron-encoded endonuclease I-SceI	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process DNA recombination DNA metabolic process intron homing mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B]	IPR004860	Homing endonuclease, LAGLIDADG	Domain
E [auth A], F [auth B]	IPR027434	Homing endonuclease	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.