Download MendeleyThe structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1.
Leroy, L., Barbosa, J.A.R.G., de Prat-Gay, G., Polikarpov, I., Pinheiro, C.B.(2020) Proteins 88: 106-112
- PubMed: 31299114
- DOI: https://doi.org/10.1002/prot.25773
- Primary Citation of Related Structures:
6BUS - PubMed Abstract:
Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3 1 21. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time.
Organizational Affiliation:
Laboratório de Cristalografia, Physics Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
