4Y99

Core domain of human cardiac troponin

  • Classification: CONTRACTILE PROTEIN
  • Organism(s): Homo sapiens
  • Expression System: Escherichia coli
  • Mutation(s): Yes 

  • Deposited: 2015-02-17 Released: 2016-03-30 
  • Deposition Author(s): Takeda, S.
  • Funding Organization(s): The ministry of Education, Culture, Sports, Science and Techinology Japan

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.00 Å
  • R-Value Free: 0.259 
  • R-Value Work: 0.230 
  • R-Value Observed: 0.232 

wwPDB Validation   3D Report Full Report


This is version 1.2 of the entry. See complete history


Literature

Core domain of human cardiac troponin

Takeda, S.Fujiwara, S.

To be published.

Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Troponin C, slow skeletal and cardiac muscles161Homo sapiensMutation(s): 2 
Gene Names: TNNC1TNNC
UniProt & NIH Common Fund Data Resources
Find proteins for P63316 (Homo sapiens)
Explore P63316 
Go to UniProtKB:  P63316
PHAROS:  P63316
GTEx:  ENSG00000114854 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP63316
Sequence Annotations
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  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
Troponin T, cardiac muscle106Homo sapiensMutation(s): 0 
Gene Names: TNNT2
UniProt & NIH Common Fund Data Resources
Find proteins for P45379 (Homo sapiens)
Explore P45379 
Go to UniProtKB:  P45379
PHAROS:  P45379
GTEx:  ENSG00000118194 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP45379
Sequence Annotations
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  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
Troponin I, cardiac muscle210Homo sapiensMutation(s): 2 
Gene Names: TNNI3TNNC1
UniProt & NIH Common Fund Data Resources
Find proteins for P19429 (Homo sapiens)
Explore P19429 
Go to UniProtKB:  P19429
PHAROS:  P19429
GTEx:  ENSG00000129991 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP19429
Sequence Annotations
Expand
  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.00 Å
  • R-Value Free: 0.259 
  • R-Value Work: 0.230 
  • R-Value Observed: 0.232 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 66.062α = 90
b = 80.368β = 90
c = 93.712γ = 90
Software Package:
Software NamePurpose
HKL-2000data collection
HKL-2000data scaling
MOLREPphasing
REFMACrefinement
PDB_EXTRACTdata extraction

Structure Validation

View Full Validation Report



Entry History & Funding Information

Deposition Data

  • Released Date: 2016-03-30 
  • Deposition Author(s): Takeda, S.

Funding OrganizationLocationGrant Number
The ministry of Education, Culture, Sports, Science and Techinology JapanJapan--

Revision History  (Full details and data files)

  • Version 1.0: 2016-03-30
    Type: Initial release
  • Version 1.1: 2020-02-05
    Changes: Data collection, Derived calculations
  • Version 1.2: 2023-11-08
    Changes: Data collection, Database references, Refinement description