4A04

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.58 Å
  • R-Value Free: 0.227 
  • R-Value Work: 0.206 
  • R-Value Observed: 0.208 

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This is version 1.5 of the entry. See complete history. 


Literature

Structure of the DNA-Bound T-Box Domain of Human Tbx1, a Transcription Factor Associated with the Digeorge Syndrome

El Omari, K., De Mesmaeker, J., Karia, D., Ginn, H., Bhattacharya, S., Mancini, E.J.

(2012) Proteins 80: 655


Macromolecules

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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
T-BOX TRANSCRIPTION FACTOR TBX1
A, B
203Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for O43435 (Homo sapiens)
Explore O43435 
Go to UniProtKB:  O43435
PHAROS:  O43435
GTEx:  ENSG00000184058 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupO43435
Sequence Annotations
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  • Reference Sequence

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Entity ID: 2
MoleculeChains LengthOrganismImage
DNAC [auth D],
D [auth E]		24Homo sapiens
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.58 Å
  • R-Value Free: 0.227 
  • R-Value Work: 0.206 
  • R-Value Observed: 0.208 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 71.42α = 90
b = 92.74β = 90
c = 101.02γ = 90
Software Package:
Software NamePurpose
BUSTERrefinement
xia2data reduction
xia2data scaling
MOLREPphasing

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2011-10-12
    Type: Initial release
  • Version 1.1: 2011-10-26
    Changes: Structure summary
  • Version 1.2: 2011-11-30
    Changes: Database references
  • Version 1.3: 2012-04-18
    Changes: Other
  • Version 1.4: 2012-09-12
    Changes: Refinement description
  • Version 1.5: 2023-12-20
    Changes: Data collection, Database references, Other, Refinement description