2XSN

Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.68 Å
  • R-Value Free: 0.222 
  • R-Value Work: 0.189 
  • R-Value Observed: 0.191 

wwPDB Validation   3D Report Full Report


This is version 1.2 of the entry. See complete history. 


Literature

Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain

Muniz, J.R.C., Cooper, C.D.O., Yue, W.W., Krysztofinska, E., von Delft, F., Knapp, S., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.

To be published.

Macromolecules
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(by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
TYROSINE 3-MONOOXYGENASE
A, B, C, D
343Homo sapiensMutation(s): 1 
EC: 1.14.16.2
UniProt & NIH Common Fund Data Resources
Find proteins for P07101 (Homo sapiens)
Explore P07101 
Go to UniProtKB:  P07101
PHAROS:  P07101
GTEx:  ENSG00000180176 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP07101
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.68 Å
  • R-Value Free: 0.222 
  • R-Value Work: 0.189 
  • R-Value Observed: 0.191 
  • Space Group: P 65 2 2
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 191.42α = 90
b = 191.42β = 90
c = 168.16γ = 120
Software Package:
Software NamePurpose
BUSTER-TNTrefinement
MOSFLMdata reduction
SCALAdata scaling
PHASERphasing

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2010-11-17
    Type: Initial release
  • Version 1.1: 2012-12-05
    Changes: Database references, Source and taxonomy, Structure summary, Version format compliance
  • Version 1.2: 2018-01-24
    Changes: Database references, Structure summary