Structure of the RNA-dependent RNA polymerase of poliovirus.
Hansen, J.L., Long, A.M., Schultz, S.C.(1997) Structure 5: 1109-1122
- PubMed: 9309225 
- DOI: https://doi.org/10.1016/s0969-2126(97)00261-x
- Primary Citation of Related Structures:  
1RDR - PubMed Abstract: 
The central player in the replication of RNA viruses is the viral RNA-dependent RNA polymerase. The 53 kDa poliovirus polymerase, together with other viral and possibly host proteins, carries out viral RNA replication in the host cell cytoplasm. RNA-dependent RNA polymerases comprise a distinct category of polymerases that have limited sequence similarity to reverse transcriptases (RNA-dependent DNA polymerases) and perhaps also to DNA-dependent polymerases. Previously reported structures of RNA-dependent DNA polymerases, DNA-dependent DNA polymerases and a DNA-dependent RNA polymerase show that structural and evolutionary relationships exist between the different polymerase categories.
Organizational Affiliation: 
Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309, USA.