Download MendeleyThe structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
Pedelacq, J.D., Maveyraud, L., Prevost, G., Baba-Moussa, L., Gonzalez, A., Courcelle, E., Shepard, W., Monteil, H., Samama, J.P., Mourey, L.(1999) Structure 7: 277-287
- PubMed: 10368297
- DOI: https://doi.org/10.1016/s0969-2126(99)80038-0
- Primary Citation of Related Structures:
1PVL - PubMed Abstract:
Leucocidins and gamma-hemolysins are bi-component toxins secreted by Staphylococcus aureus. These toxins activate responses of specific cells and form lethal transmembrane pores. Their leucotoxic and hemolytic activities involve the sequential binding and the synergistic association of a class S and a class F component, which form hetero-oligomeric complexes. The components of each protein class are produced as non-associated, water-soluble proteins that undergo conformational changes and oligomerization after recognition of their cell targets.
Organizational Affiliation:
Groupe de Cristallographie Biologique Institut de Pharmacologie et de Biologie Structurale du CNRS 205 route de Narbonne 31077 Toulouse Cedex France.
