5KQV
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
External Resource: Annotation
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Insulin-like | 8072339 | 3000307 | SCOP2B (2022-06-29) |
G [auth I] | SCOP2B Superfamily | Insulin-like | 8072339 | 3000307 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Growth factor receptor domain-like | 8032837 | 3000398 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | L domain-like | 8032830 | 3001010 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | L domain-like | 8032832 | 3001010 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Growth factor receptor domain-like | 8032837 | 3000398 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | L domain-like | 8032832 | 3001010 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | L domain-like | 8032830 | 3001010 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00049 | e5kqvA1 | A: few secondary structure elements | X: Insulin-like (From Topology) | H: Insulin-like (From Topology) | T: Insulin-like | F: PF00049 | ECOD (1.6) |
G [auth I] | PF00049 | e5kqvI1 | A: few secondary structure elements | X: Insulin-like (From Topology) | H: Insulin-like (From Topology) | T: Insulin-like | F: PF00049 | ECOD (1.6) |
C | PF07654 | e5kqvC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
C | PF07686 | e5kqvC2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
I [auth P] | PF07654 | e5kqvP1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
I [auth P] | PF07686 | e5kqvP2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
J [auth Q] | PF07654 | e5kqvQ1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
J [auth Q] | PF07686 | e5kqvQ2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
D | PF07654 | e5kqvD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
D | PF07686 | e5kqvD2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
E | F_UNCLASSIFIED | e5kqvE3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
E | PF01030 | e5kqvE1 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF01030 | ECOD (1.6) |
E | PF00757 | e5kqvE4 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: PF00757 | ECOD (1.6) |
F | F_UNCLASSIFIED | e5kqvF1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
F | PF01030 | e5kqvF3 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF01030 | ECOD (1.6) |
F | PF00757 | e5kqvF2 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: PF00757 | ECOD (1.6) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
C, I [auth P] | Fab 83-14 | VH-CH1 | Mus musculus (house mouse) | IGHV1S56*01, IGHJ3*01, IGHG2A*01, IGHG2A*02 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-2A_KAPPA | IMGT (202421-0) |
D, J [auth Q] | Fab 83-14 | L-KAPPA | Mus musculus (house mouse) | IGKV9-120*01, IGKJ1*01, IGKC*01, IGKC*02 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-2A_KAPPA | IMGT (202421-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
C, I [auth P] | Heavy Chain | IGHV1 | - | insulin receptor,insulin receptor | SAbDab (2024-05-31) |
D, J [auth Q] | Light Chain | IGKV9 | Kappa | insulin receptor,insulin receptor | SAbDab (2024-05-31) |
Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage
Chain | Name | Target | Provenance Source |
---|---|---|---|
C, I [auth P] | Valanafusp | INSR/CD220 | Therapeutic SAbDab (2024-05-31) |
D, J [auth Q] | Valanafusp | INSR/CD220 | Therapeutic SAbDab (2024-05-31) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, G [auth I] | PF00049 | Insulin/IGF/Relaxin family (Insulin) | Insulin/IGF/Relaxin family | Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. | Domain |
B, H [auth J] | PF00049 | Insulin/IGF/Relaxin family (Insulin) | Insulin/IGF/Relaxin family | Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. | Domain |
PF00757 | Furin-like cysteine rich region (Furin-like) | Furin-like cysteine rich region | - | Domain | |
PF01030 | Receptor L domain (Recep_L_domain) | Receptor L domain | - | Repeat |